All Outputs (9)

Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis (2024)
Journal Article
Alqarni, F., Akbar, T., Fatani, H., Kumasaka, S., Hoad, C. L., Spiller, R. C., Taylor, M. A., & Marciani, L. (2024). Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis. Diagnostics, 14(19), Article 2190. https://doi.org/10.3390/diagnostics14192190

Abstract: Purpose: Knowledge of the length of the colon is relevant to understanding physiological and pathological function. It also has implications for diagnostic and clinical interventions, as well as for the design of delayed-release drug form... Read More about Experimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis.

Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, Article 115090. https://doi.org/10.1016/j.foodres.2024.115090

White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.

Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents (2024)
Journal Article
Molinar-Díaz, J., Arjuna, A., Abrehart, N., McLellan, A., Harris, R., Islam, M. T., Alzaidi, A., Bradley, C. R., Gidman, C., Prior, M. J. W., Titman, J., Blockley, N. P., Harvey, P., Marciani, L., & Ahmed, I. (2024). Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents. Molecules, 29(18), Article 4296. https://doi.org/10.3390/molecules29184296

In this research, resorbable phosphate-based glass (PBG) compositions were developed using varying modifier oxides including iron (Fe2O3), copper (CuO), and manganese (MnO2), and then processed via a rapid single-stage flame spheroidisation process t... Read More about Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (in press). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut,

Background
Colonic motility in constipation can be assessed non-invasively using MRI

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43 p... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Intra‐ and interindividual variability in fasted gastric content volume (2024)
Journal Article
Roelofs, J. J. M., Camps, G., Leenders, L. M., Marciani, L., Spiller, R. C., Van Eijnatten, E. J. M., Alyami, J., Deng, R., Freitas, D., Grimm, M., Karhunen, L. J., Krishnasamy, S., Le Feunteun, S., Lobo, D. N., Mackie, A. R., Mayar, M., Weitschies, W., & Smeets, P. A. M. (in press). Intra‐ and interindividual variability in fasted gastric content volume. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14904

Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra-and interindividual... Read More about Intra‐ and interindividual variability in fasted gastric content volume.

Intra- and interindividual variability in fasted gastric content volume (2024)
Journal Article
Roelofs, J. J., Camps, G., Leenders, L. M., Marciani, L., Spiller, R. C., van Eijnatten, E. J., Alyami, J., Denga, R., Freitas, D., Grimm, M., Karhunen, L. J., Krishnasamy, S., Le Feunteung, S., Lobo, D. N., Mackiei, A. R., Mayar, M., Weitschies, W., & Smeets, P. A. (2024). Intra- and interindividual variability in fasted gastric content volume. Neurogastroenterology and Motility, Article e14904. https://doi.org/10.1111/nmo.14904

Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual... Read More about Intra- and interindividual variability in fasted gastric content volume.

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study (2024)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., …Smyth, A. R. (2024). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. NIHR Open Research, 3, Article 65. https://doi.org/10.3310/nihropenres.13510.2

Background
People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung funct... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.

The impact of heat treatment of bovine milk on gastric emptying and nutrient appearance in peripheral circulation in healthy females: a randomized controlled trial comparing pasteurized and ultra-high temperature milk (2024)
Journal Article
Milan, A. M., Barnett, M. P., McNabb, W. C., Roy, N. C., Coutinho, S., Hoad, C. L., …Mithen, R. F. (2024). The impact of heat treatment of bovine milk on gastric emptying and nutrient appearance in peripheral circulation in healthy females: a randomized controlled trial comparing pasteurized and ultra-high temperature milk. American Journal of Clinical Nutrition, 119(5), 1200-1215. https://doi.org/10.1016/j.ajcnut.2024.03.002

Background: Heat treatments of dairy, including pasteurization and ultra-high temperature (UHT) processing, alter milk macromolecular structures, and ultimately affect digestion. In vitro, animal, and human studies show faster nutrient release or cir... Read More about The impact of heat treatment of bovine milk on gastric emptying and nutrient appearance in peripheral circulation in healthy females: a randomized controlled trial comparing pasteurized and ultra-high temperature milk.

Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review (2024)
Journal Article
Akbar, T., Gershkovich, P., Stamatopoulos, K., Gowland, P. A., Stolnik, S., Butler, J., & Marciani, L. (2024). Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review. Molecular Pharmaceutics, 21(4), 1553-1562. https://doi.org/10.1021/acs.molpharmaceut.3c01123

Oral dosage forms are the most widely and frequently used formulations to deliver active pharmaceutical ingredients (APIs), due to their ease of administration and noninvasiveness. Knowledge of intragastric release rates and gastric mixing is crucial... Read More about Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review.