Research Repository

See what's under the surface


Assessment of the cellular localisation of the Annexin A2/S100A10 complex in human placenta (2018)
Journal Article
Seham, E., & Lodewijk, D. (2018). Assessment of the cellular localisation of the Annexin A2/S100A10 complex in human placenta. Journal of Molecular Histology, doi:10.1007/s10735-018-9791-2. ISSN 1567-2379

The AnxA2/S100A10 complex has been implicated in various placental functions but although the localisation of these proteins individually has been studied, there is no information about the localisation of their complex in situ at the cellular leve... Read More

Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells (2017)
Journal Article
Ahmed, M., Chaudhari, K., Babaei‐Jadidi, R., Dekker, L. V., & Shams Nateri, A. (2017). Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells. STEM CELLS, 35(4), 839-850. doi:10.1002/stem.2579

Increasing evidence suggests that cancer cell populations contain a small proportion of cells that display stem‐like cell properties and which may be responsible for overall tumor maintenance. These cancer stem‐like cells (CSCs) appear to have unique... Read More

Alkylation of staurosporine to derive a kinase probe for fluorescence applications (2016)
Journal Article
Disney, A. J., Kellam, B., & Dekker, L. V. (in press). Alkylation of staurosporine to derive a kinase probe for fluorescence applications. ChemMedChem, 11, doi:10.1002/cmdc.201500589. ISSN 1860-7179

The natural product staurosporine is a high-affinity inhibitor of nearly all mammalian protein kinases.The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acyla... Read More

Coagulation factor XII protease domain crystal structure (2015)
Journal Article
Pathak, M., Wilmann, P., Awford, J., Li, C., Hamad, B., Fischer, P., …Emsley, J. (2015). Coagulation factor XII protease domain crystal structure. Journal of Thrombosis and Haemostasis, 13(4), 580-591. doi:10.1111/jth.12849

Background: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI. Objective: To investigate FXII zymogen activation and substrate recognition by d... Read More