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All Outputs (44)

An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogels (2021)
Journal Article
Zhou, Z., Samperi, M., Santu, L., Dizon, G., Aboarkaba, S., Limón, D., …Wildman, R. (2021). An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogels. Materials and Design, 206, Article 109792. https://doi.org/10.1016/j.matdes.2021.109792

The variety of UV-curable monomers for 3D printing is limited by a requirement for rapid curing after each sweep depositing a layer. This study proposes to trigger supramolecular self-assembly during the process by a gemini imidazolium-based low-mole... Read More about An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogels.

Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles (2020)
Other
Jain, A., Trindade, G., Hicks, J. M., Potts, J. C., Rahman, R., Hague, R., …Rawson, F. Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorpti... Read More about Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles.

Enhancing singlet oxygen generation by self-assembly of a porphyrin entrapped in supramolecular fibres (2020)
Journal Article
Samperi, M., Limo, D., Amabilino, D. B., & Perez-Garc?a, L. (2020). Enhancing singlet oxygen generation by self-assembly of a porphyrin entrapped in supramolecular fibres. Cell Reports Physical Science, 1(3), https://doi.org/10.1016/jxcrp.2020.100030

Singlet oxygen (SO) is one of the reactive oxygen species that is effective in various uses, including performing chemical reactions, treating water impurities, and aiding in medicinal therapy. The generation of SO is often efficient in solution, alt... Read More about Enhancing singlet oxygen generation by self-assembly of a porphyrin entrapped in supramolecular fibres.

Quantification of energy of activation to supramolecular nanofibre formation reveals enthalpic and entropic effects and morphological consequence (2019)
Journal Article
Samperi, M., Perez-Garcia, L., & Amabilino, D. B. (2019). Quantification of energy of activation to supramolecular nanofibre formation reveals enthalpic and entropic effects and morphological consequence. Chemical Science, 2019(44), 10256-10266. https://doi.org/10.1039/c9sc03280k

We show a self-assembly process leading to fibres from a system that starts far from equilibrium because of fast solvent – anti-solvent mixing and analyse the activation energies associated with the aggregation. It is in some ways reminiscent of dive... Read More about Quantification of energy of activation to supramolecular nanofibre formation reveals enthalpic and entropic effects and morphological consequence.

Wireless Nanobioelectronics for Electrical Intracellular Sensing (2019)
Journal Article
Sanjuan-Alberte, P., Jain, A., Shaw, A. J., Abayzeed, S. A., Domínguez, R. F., Alea-Reyes, M. E., …Rawson, F. J. (2019). Wireless Nanobioelectronics for Electrical Intracellular Sensing. ACS Applied Nano Materials, 2(10), 6397-6408. https://doi.org/10.1021/acsanm.9b01374

For the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of “wireless” electronic systems to enable modulation of chemistry inside of cells. Herein we report on an intracellular wireless elec... Read More about Wireless Nanobioelectronics for Electrical Intracellular Sensing.

Nanostructured supramolecular hydrogels: Towards the topical treatment of Psoriasis and other skin diseases (2019)
Journal Article
Limón, D., Talló Domínguez, K., Garduño-Ramírez, M. L., Andrade, B., Calpena, A. C., & Pérez-García, L. (2019). Nanostructured supramolecular hydrogels: Towards the topical treatment of Psoriasis and other skin diseases. Colloids and Surfaces B: Biointerfaces, 181, 657-670. https://doi.org/10.1016/j.colsurfb.2019.06.018

Supramolecular hydrogels were synthesized using a bis-imidazolium based amphiphile, and incorporating chemically diverse drugs, such as the cytostatics gemcitabine hydrochloride and methotrexate sodium salt, the immunosuppressive drug tacrolimus, as... Read More about Nanostructured supramolecular hydrogels: Towards the topical treatment of Psoriasis and other skin diseases.

Controlling the preferential motion of chiral molecular walkers on a surface (2019)
Journal Article
Abbasi-Pérez, D., Sang, H., Pérez-García, L., Floris, A., Amabilino, D. B., Raval, R., …Kantorovich, L. (2019). Controlling the preferential motion of chiral molecular walkers on a surface. Chemical Science, 10(23), 5864-5874. https://doi.org/10.1039/c9sc01135h

Molecular walkers standing on two or more “feet” on an anisotropic periodic potential of a crystal surface may perform a one-dimensional Brownian motion at the surface-vacuum interface along a particular direction in which their mobility is the large... Read More about Controlling the preferential motion of chiral molecular walkers on a surface.

Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling (2019)
Journal Article
Starr, N. J., Hamid, K. A., Wibawa, J., Marlow, I., Bell, M., Pérez-García, L., …Scurr, D. J. (2019). Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling. International Journal of Pharmaceutics, 563, 21-29. https://doi.org/10.1016/j.ijpharm.2019.03.028

Vitamin C (ascorbic acid) is a naturally occurring, powerful anti-oxidant with the potential to deliver numerous benefits to the skin when applied topically. However, topical use of this compound is currently restricted by an instability in tradition... Read More about Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling.

Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles (2019)
Journal Article
Bruce, G., Samperi, M., Amabilino, D. B., Duch, M., Plaza, J. A., & Pérez-García, L. (2019). Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles. Journal of Porphyrins and Phthalocyanines, 23(01n02), 223-233. https://doi.org/10.1142/s1088424619500226

© 2019 World Scientific Publishing Company. The generation of singlet oxygen (SO), primarily by using a combination of light and photosensitizers in the presence of a dissolved gas, finds applications in both chemistry and medicine. The efficiency of... Read More about Singlet oxygen generation from porphyrin-functionalized hexahedral polysilicon microparticles.

Wireless bioelectronic nanosystems for intracellular communication (2018)
Other
Sanjuán-Alberte, P., Abayzeed, S. A., Fuentes-Domínguez, R., Alea-Reyesd, M. E., Clark, M., Hague, R., …Rawson, F. (2018). Wireless bioelectronic nanosystems for intracellular communication

In order for the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of “wireless” electronic systems to both sense and actuate cell behaviour. Herein we report the first example of an innovativ... Read More about Wireless bioelectronic nanosystems for intracellular communication.

Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer (2018)
Journal Article
García Calavia, P., Bruce, G., Pérez-García, L., & Russell, D. A. (2018). Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer. Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, 17(11), 1534-1552. https://doi.org/10.1039/c8pp00271a

Gold nanoparticles (AuNPs) have been extensively studied within biomedicine due to their biocompatibility and low toxicity. In particular, AuNPs have been widely used to deliver photosensitiser agents for photodynamic therapy (PDT) of cancer. Here we... Read More about Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer.

Synthesis and in vitro phototoxicity of multifunctional Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin-coated gold nanoparticles assembled via axial coordination with imidazole ligands (2018)
Journal Article
Alea-Reyes, M. E., Penon, O., García Calavia, P., Marín, M. J., Russell, D. A., & Pérez-García, L. (2018). Synthesis and in vitro phototoxicity of multifunctional Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin-coated gold nanoparticles assembled via axial coordination with imidazole ligands. Journal of Colloid and Interface Science, 521, https://doi.org/10.1016/j.jcis.2018.03.014

Hypothesis Metalloporphyrins are extensively investigated for their ability to form reactive oxygen species and as potent photosensitisers for use in photodynamic therapy. However, their hydrophobicity generally causes solubility issues concerning... Read More about Synthesis and in vitro phototoxicity of multifunctional Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin-coated gold nanoparticles assembled via axial coordination with imidazole ligands.

Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases (2018)
Journal Article
Limón, D., Fábrega, M. J., Calpena, A. C., Badia, J., Baldomà, L., & Pérez-García, L. (2018). Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases. Bioconjugate Chemistry, 28(4), https://doi.org/10.1021/acs.bioconjchem.7b00717

The overexpression and increased activity of the serine protease Kallikrein 5 (KLK5) is characteristic of inflammatory skin diseases such as Rosacea. The use of inhibitors of this enzyme—such as 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride... Read More about Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases.

Drug-Loaded Supramolecular Gels Prepared in a Microfluidic Platform: Distinctive Rheology and Delivery through Controlled Far-from-Equilibrium Mixing (2017)
Journal Article
Sathyanarayanan, G., Rodrigues, M., Limón, D., Rodriguez-Trujillo, R., Puigmartí-Luis, J., Pérez-García, L., & Amabilino, D. B. (2017). Drug-Loaded Supramolecular Gels Prepared in a Microfluidic Platform: Distinctive Rheology and Delivery through Controlled Far-from-Equilibrium Mixing. ACS Omega, 2(12), 8849-8858. https://doi.org/10.1021/acsomega.7b01800

It is shown here that controlled mixing of a gelator, drug, solvent, and antisolvent in a microfluidic channel leads to faster setting gels and more robust materials with longer release profiles than the physical gels of the same composition obtained... Read More about Drug-Loaded Supramolecular Gels Prepared in a Microfluidic Platform: Distinctive Rheology and Delivery through Controlled Far-from-Equilibrium Mixing.

Amphiphilic Gemini Pyridinium-mediated incorporation of Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin into water-soluble gold nanoparticles for photodynamic therapy (2017)
Journal Article
Alea-Reyes, M. E., Soriano, J., Mora-Espí, I., Rodrigues, M., Russell, D. A., Barrios, L., & Pérez-García, L. (2017). Amphiphilic Gemini Pyridinium-mediated incorporation of Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin into water-soluble gold nanoparticles for photodynamic therapy. Colloids and Surfaces B: Biointerfaces, 158, https://doi.org/10.1016/j.colsurfb.2017.07.033

Zn-containing porphyrins are intensely investigated for their ability to form reactive oxygen species and thereby being potent photosensitizers for use in photodynamic therapy (PDT). Some of the drawbacks of the PDT approach, such as unspecific distr... Read More about Amphiphilic Gemini Pyridinium-mediated incorporation of Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin into water-soluble gold nanoparticles for photodynamic therapy.

Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery (2017)
Journal Article
Limon, D., Jimenez-Newman, C., Rodrigues, M., Gonzalez-Campo, A., Amabilino, D. B., Calpena, A. C., & Pérez-García, L. (2017). Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery. ChemistryOpen, 6(4), https://doi.org/10.1002/open.201700040

A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and con... Read More about Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery.

Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery (2017)
Journal Article
Alea-Reyes, M. E., Gonzalez, A., Calpena, A. C., Ramos-López, D., Lapuente, J. D., & Pérez-García, L. (2017). Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery. Journal of Colloid and Interface Science, 502, https://doi.org/10.1016/j.jcis.2017.04.064

Hypothesis Gemini pyridinium-based amphiphiles can play a triple role as: gold nanoparticles (AuNPs) synthesis facilitator, particle stabilizer and anion recognition centre. The so formed nanoparticles should be able to bind and release anionic dr... Read More about Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery.

Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor (2017)
Journal Article
Limón, D., Jiménez-Newman, C., Calpena, A. C., González-Campo, A., Amabilino, D. B., & Pérez-García, L. (in press). Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor. Chemical Communications, 53(32), 4509-4512. https://doi.org/10.1039/C6CC09392B

© The Royal Society of Chemistry. Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affect... Read More about Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor.

Nanostructured materials for photodynamic therapy: synthesis, characterization and in vitro activity (2017)
Journal Article
Alea-Reyes, M. E., Rodrigues, M., Serra, A., Mora, M., Sagrista, M. L., Gonzalez, A., …Pérez-García, L. (in press). Nanostructured materials for photodynamic therapy: synthesis, characterization and in vitro activity. RSC Advances, 7, https://doi.org/10.1039/c7ra01569k

Three nanostructured vehicles are proposed as potential carriers for photosensitizers to be used in photodynamic therapy: spherical nanoparticles, hexahedral microparticles and cylindrical magnetic nanorods. A comparative study of their photodynamic... Read More about Nanostructured materials for photodynamic therapy: synthesis, characterization and in vitro activity.

Highly Anisotropic Suspended Planar-Array Chips with Multidimensional Sub-Micrometric Biomolecular Patterns (2017)
Journal Article
Agusil, J. P., Torras, N., Duch, M., Esteve, J., Pérez-García, L., Samitier, J., & Plaza, J. A. (2017). Highly Anisotropic Suspended Planar-Array Chips with Multidimensional Sub-Micrometric Biomolecular Patterns. Advanced Functional Materials, 27(13), 1-11. https://doi.org/10.1002/adfm.201605912

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Suspended planar-array (SPA) chips embody millions of individual miniaturized arrays to work in extremely small volumes. Here, the basis of a robust methodology for the fabrication of SPA silicon ch... Read More about Highly Anisotropic Suspended Planar-Array Chips with Multidimensional Sub-Micrometric Biomolecular Patterns.