Research Repository

See what's under the surface


Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro (2018)
Journal Article
Nizamudeen, Z. A., Chakrabarti, L., & Sottile, V. (2018). Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro. Stem Cell Research, 28, doi:10.1016/j.scr.2018.02.001. ISSN 1873-5061

Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid haemorrhage. It is known to have a positive effect on animal models of neurological disorders inc... Read More

Mouse mitochondrial lipid composition is defined by age in brain and muscle (2017)
Journal Article
Pollard, A. K., Ortori, C. A., Stöger, R., Barrett, D. A., & Chakrabarti, L. (in press). Mouse mitochondrial lipid composition is defined by age in brain and muscle. Aging, 9(3), doi:10.18632/aging.101204. ISSN 1945-4589

Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges. Ultra-hi... Read More

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease (2017)
Journal Article
Stöger, R., Scaife, P., Shephard, F., & Chakrabarti, L. (in press). Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease. npj Parkinson's Disease, 3(6), doi:10.1038/s41531-017-0007-3. ISSN 2373-8057

5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immu... Read More

Proteomic profiling of mitochondria: what does it tell us about the ageing brain? (2016)
Journal Article
Ingram, T., & Chakrabarti, L. (2016). Proteomic profiling of mitochondria: what does it tell us about the ageing brain?. Aging, 8(12), doi:10.18632/aging.101131. ISSN 1945-4589

Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have m... Read More

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration (2016)
Journal Article
Pollard, A., Shephard, F., Freed, J., Liddell, S., & Chakrabarti, L. (2016). Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration. Aging, 8(10), doi:10.18632/aging.101064. ISSN 1945-4589

Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons. However, there is little information about carbonic anhydrase... Read More

Analysis of mitochondrial haemoglobin in Parkinson's disease brain (2016)
Journal Article
Shephard, F., Greville-Heygate, O., Liddell, S., Emes, R. D., & Chakrabarti, L. (2016). Analysis of mitochondrial haemoglobin in Parkinson's disease brain. Mitochondrion, 29, doi:10.1016/j.mito.2016.05.001. ISSN 1567-7249

Mitochondrial dysfunction is an early feature of neurodegeneration. We have shown there are mitochondrial haemoglobin changes with age and neurodegeneration. We hypothesised that altered physiological processes are associated with recruitment and loc... Read More