Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial

Bath, Philip M; Scutt, Polly; Anderson, Craig S; Appleton, Jason P; Berge, Evind; Cala, Lesley; Dixon, Mark; England, Timothy M; Godolphin, Peter J; Havard, Diane; Haywood, Lee; Hepburn, Trish; Krishnan, Kailash; Mair, Grant; Montgomery, Alan A; Muir, Keith; Phillips, Stephen J; Pocock, Stuart; Potter, John; Price, Chris; Randall, Marc; Robinson, Thompson G; Roffe, Christine; Rothwell, Peter M; Sandset, Else C; Sanossian, Nerses; Saver, Jeffrey L; Shone, Angela; Niroshan Siriwardena, A; Wardlaw, Joanna M; Woodhouse, Lisa J; Venables, Graham; Sprigg, Nikola; Amarenco, Pierre; Muir, Keith; Amoils, Shannon; Jarvis, Malcolm; Rothwell, Peter M; Sandercock, Peter; Asplund, Kjell; Baigent, Colin; Ankolekar, Sandeep; Howard, Harriet; Lysons, Christopher; Walker, Gemma; Gregory, Hayley; Kirby, James; Smithson, Jennifer; Keeling, Joanne; Frowd, Nadia; Gray, Robert; Dooley, Richard; Clarke, Wim; Robinson, Patricia; Kang Law, Zhe; Hodgson, Sheila; Millington, Adam; Sakka, Eleni; Buchanan, David; Palmer, Jeb; Shaw, D; Cobb, H; Johnson, R; Payne, T; Spaight, R; Spaight, A; Sajid, M A; Whileman, A; Hall, E; Cripps, H; Toms, J; Gascoyne, R; Wright, S; Cooper, M; Palfreman, A; Rajapakse, A; Wynter, I; Musarrat, K; Mistri, A; Patel, C; Stephens, C; Khan, S; Patras, S; Soliman, M; Elmarimi, A; Hewitt, C; Watson, E; Wahishi, I; Hindle, J; Perkin, L; Wills, M; Arif, S; Leach, S; Butler, S; O'Kane, D; Smith, C; O'Callaghan, J; Sunman, W; Buck, A; Jackson, B; Richardson, C; Wilkes, G; Clarke, J; Ryan, L; Matias, O; Mangion, D; Hardwick, A; Constantin, C; Thomas, I; Netherton, K; Markova, S; Hedstrom, A; Rushton, B; Hyde, C; Scott, J; Blair, M; Maddula, M; Donnelly, R; Keane, S; Johnson, S; McKenzie, H; Banerjee, A; Hutchinson, D; Goodhand, H; Hill, J; Mellows, K; Cheeseman, M; McTaggart, V; Foster, T; Prothero, L; Saksena, P; O'Kelly, A; Wyllie, H; Hacon, C; Nutt, H; North, J; Goffin, K; Potter, J; Wiltshire, A; Ravenhill, G; Metcalf, K; Ford, L; Langley, M; Davison, W; Subramonian, S; Magezi, F; Obi, I; Temple, N; Butterworth-Cowin, N; Oqwusu-Agyei, P; Azim, A F M; Nicolson, A; Imam, J; White, J; Wood, L; Fothergill, R; Thompson, N; Lazarus, J; Werts, H; Sztriha, L; Ho, C; McKenzie, E; Owoyele, E; Lim, J; Aeron-Thomas, J; Dockey, M; Sylvester, N; Rao, P; Bloom, B M; Erumere, E; Norman, G; Skene, I; Cuenoud, L; Howaniec, L; Boulton, O; Daboo, P; Michael, R; Al-Saadi, S; Harrison, T; Syed, H; Argandona, L; Amiani, S; Perry, R; Ashton, A; Banaras, A; Hogan, C; Watchurst, C; Elliott, E; Francia, N; Oji, N; Erande, R; Obarey, S; Feerick, S; Tshuma, S; England, E; Pocock, H; Poole, K; Manchanda, S; Burn, I; Dayal, S; McNee, K; Robinson, M; Hancock, R; South, A; Holmes, C; Steele, A; Guthrie, L B; Oborn, M; Mohd Nor, A; Hyams, B; Eglinton, C; Waugh, D; Cann, E; Wilmhurst, N; Piesley, S; Shave, S; Dutta, D; Obeid, M; Ward, D; Turfrey, J; Glass, J; Bowstead, K; Hill, L; Brown, P; Beames, S; O'Connell, S; Hughes, V; Whiting, R; Gagg, J; Hussain, M; Harvey, M; Karunatilake, D; Pusuluri, B; Witcher, A; 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doi:10.1016/S0140-6736(19)30194-1

All Outputs (2)

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial (2019)
Journal Article
Appleton, J., Blair, G. W., Flaherty, K., Law, Z., May, J., Woodhouse, L. J., …Wardlow, J. M. (2019). Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial. Frontiers in Neurology, 10, 1-6. https://doi.org/10.3389/fneur.2019.00723

Background Cilostazol and isosorbide mononitrate (ISMN) are candidate treatments for cerebral small vessel disease and lacunar ischaemic stroke. As both drugs may influence haemoglobin and platelet count, and haemodynamics, we sought to assess their... Read More about Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial.