All Outputs (4)

Proteomic profiling of mitochondria: what does it tell us about the ageing brain? (2016)
Journal Article
Ingram, T., & Chakrabarti, L. (2016). Proteomic profiling of mitochondria: what does it tell us about the ageing brain?. Aging, 8(12), https://doi.org/10.18632/aging.101131

Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have m... Read More about Proteomic profiling of mitochondria: what does it tell us about the ageing brain?.

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration (2016)
Journal Article
Pollard, A., Shephard, F., Freed, J., Liddell, S., & Chakrabarti, L. (2016). Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration. Aging, 8(10), 2425-2436. https://doi.org/10.18632/aging.101064

Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons. However, there is little information about carbonic anhydrase... Read More about Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration.

Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration (2016)
Journal Article
Cai, H., Pollard, A. K., Craig, E. L., & Chakrabarti, L. (in press). Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration. PLoS ONE, 11(6), Article e0157405. https://doi.org/10.1371/journal.pone.0157405

Mitochondrial function, in particular complex 1 of the electron transport chain (ETC), has been shown to decrease during normal ageing and in neurodegenerative disease. However, there is some debate concerning which area of the brain has the greatest... Read More about Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration.

Analysis of mitochondrial haemoglobin in Parkinson's disease brain (2016)
Journal Article
Shephard, F., Greville-Heygate, O., Liddell, S., Emes, R. D., & Chakrabarti, L. (2016). Analysis of mitochondrial haemoglobin in Parkinson's disease brain. Mitochondrion, 29, 45-52. https://doi.org/10.1016/j.mito.2016.05.001

Mitochondrial dysfunction is an early feature of neurodegeneration. We have shown there are mitochondrial haemoglobin changes with age and neurodegeneration. We hypothesised that altered physiological processes are associated with recruitment and loc... Read More about Analysis of mitochondrial haemoglobin in Parkinson's disease brain.