Research Repository

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Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway (2018)
Journal Article
Band, L. R., & Preston, S. P. (in press). Parameter inference to motivate asymptotic model reduction: an analysis of the gibberellin biosynthesis pathway. Journal of Theoretical Biology, doi:10.1016/j.jtbi.2018.05.028. ISSN 0022-5193

Developing effective strategies to use models in conjunction with experimental data is essential to understand the dynamics of biological regulatory networks. In this study, we demonstrate how combining parameter estimation with asymptotic analysis c... Read More

Cellular patterning of Arabidopsis roots under low phosphate conditions (2018)
Journal Article
Janes, G., von Wangenheim, D., Cowling, S., Kerr, I. D., Band, L. R., French, A. P., & Bishopp, A. (2018). Cellular patterning of Arabidopsis roots under low phosphate conditions. Frontiers in Plant Science, doi:10.3389/fpls.2018.00735. ISSN 1664-462X

Phosphorus is a crucial macronutrient for plants playing a critical role in many cellular signaling and energy cycling processes. In light of this, phosphorus acquisition efficiency is an important target trait for crop improvement, but it also provi... Read More

Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network (2018)
Journal Article
Scofield, S., Murison, A., Jones, A., Fozard, J., Aida, M., & Band, L. R. (2018). Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. Development, 145(9), doi:10.1242/dev.157081

The Arabidopsis homeodomain transcription factor SHOOT MERISTEMLESS (STM) is crucial for shoot apical meristem (SAM) function, yet the components and structure of the STMgene regulatory network (GRN) are largely unknown. Here, we show that transcript... Read More

Root hydrotropism is controlled via a cortex-specific growth mechanism (2017)
Journal Article
Dietrich, D., Pang, L., Kobayashi, A., Fozard, J. A., Boudolf, V., Bhosale, R., …Bennett, M. J. (in press). Root hydrotropism is controlled via a cortex-specific growth mechanism. Nature Plants, 3, doi:10.1038/nplants.2017.57. ISSN 2055-026X

Plants can acclimate by using tropisms to link the direction of growth to environmental conditions. Hydrotropism allows roots to forage for water, a process known to depend on abscisic acid (ABA) but whose molecular and cellular basis remains unclear... Read More

Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis (2016)
Journal Article
Xuan, W., Band, L. R., Kumpf, R. P., Van Damme, D., Parizot, B., De Rop, G., …Beeckman, T. (2016). Cyclic programmed cell death stimulates hormone signaling and root development in Arabidopsis. Science, 351(6271), doi:10.1126/science.aad2776. ISSN 0036-8075

The plant root cap, surrounding the very tip of the growing root, perceives and transmits environmental signals to the inner root tissues. In Arabidopsis thaliana, auxin released by the root cap contributes to the regular spacing of lateral organs al... Read More

Systems analysis of auxin transport in the Arabidopsis root apex (2014)
Journal Article
Band, L. R., Wells, D. M., Fozard, J. A., Ghetiu, T., French, A. P., Pound, M. P., …Bennett, M. J. (2014). Systems analysis of auxin transport in the Arabidopsis root apex. Plant Cell, 26(3), 862-875. doi:10.1105/tpc.113.119495

Auxin is a key regulator of plant growth and development. Within the root tip, auxin distribution plays a crucial role specifying developmental zones and coordinating tropic responses. Determining how the organ-scale auxin pattern is regulated at the... Read More

Sequential induction of auxin efflux and influx carriers regulates lateral root emergence (2013)
Journal Article
Peret, B., Middleton, A. M., French, A. P., Larrieu, A., Bishopp, A., Njo, M., …Bennett, M. J. (2013). Sequential induction of auxin efflux and influx carriers regulates lateral root emergence. Molecular Systems Biology, 9(1), doi:10.1038/msb.2013.43. ISSN 1744-4292

In Arabidopsis, lateral roots originate from pericycle cells deep within the primary root. New lateral root primordia (LRP) have to emerge through several overlaying tissues. Here, we report that auxin produced in new LRP is transported towards the o... Read More

Multiscale modelling of auxin transport in the plant-root elongation zone (2012)
Journal Article
Band, L. R., & King, J. R. (2012). Multiscale modelling of auxin transport in the plant-root elongation zone. Journal of Mathematical Biology, 65(4), doi:10.1007/s00285-011-0472-y. ISSN 0303-6812

In the root elongation zone of a plant, the hormone auxin moves in a polar manner due to active transport facilitated by spatially distributed influx and efflux carriers present on the cell membranes. To understand how the cell-scale active transport... Read More