Research Repository

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Nucleoside based self-assembling drugs for localized drug delivery (2018)
Journal Article
Skilling, K. J., Stocks, M. J., Kellam, B., Ashford, M., Bradshaw, T., Burroughs, L., & Marlow, M. (in press). Nucleoside based self-assembling drugs for localized drug delivery. ChemMedChem, doi:10.1002/cmdc.201800063. ISSN 1860-7179

We have synthesized a range of gelators based on nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and TEM. Growth inhibition studies of gemcitabine derivatives confirmed the feasibilit... Read More

Straightforward synthesis of 2- and 2,8-substituted tetracenes (2017)
Journal Article
Woodward, S., Ackermann, M., Ahirwar, S., Burroughs, L., Robert Garrett, M., Ritchie, J., …Woodward, P. (in press). Straightforward synthesis of 2- and 2,8-substituted tetracenes. Chemistry - A European Journal, doi:10.1002/chem.201701170. ISSN 0947-6539

A simple regiospecific route to otherwise problematic substituted tetracenes is described. The diverse cores (E)- 1,2-Ar1CH2(HOCH2)C=C(CH2OH)I (Ar1 = Ph, 4-MePh, 4-MeOPh, 4-FPh) and (E)-1,2-I(HOCH2)C=C(CH2OH)I, accessed from ultra-low cost HOCH2C≡CCH... Read More

Low-cost and sustainable organic thermoelectrics based on low-dimensional molecular metals (2017)
Journal Article
Huewe, F., Steeger, A., Kostova, K., Burroughs, L., Bauer, I., Strohriegl, V., …Pflaum, J. (in press). Low-cost and sustainable organic thermoelectrics based on low-dimensional molecular metals. Advanced Materials, doi:10.1002/adma.201605682. ISSN 0935-9648

More than 70 % of the primary energy consumed world-wide is wasted, mostly as heat below 100 °C[1]. Thermoelectric generators may convert a substantial amount of this energy into electrical power but high production costs and scarcity of efficient th... Read More

Efficient preparation of TMSCCl2Br and its use in dichlorocyclopropanation of electron deficient alkenes (2016)
Journal Article
Lee, D. S., Durán-Peña, M. J., Burroughs, L., & Woodward, S. (in press). Efficient preparation of TMSCCl2Br and its use in dichlorocyclopropanation of electron deficient alkenes. Chemistry - A European Journal, 2016(22), doi:10.1002/chem.201600607. ISSN 0947-6539

The reaction of excess TMSCl and LiCCl2Br at low temperature is a technically simple high yield route to TMSCCl2Br. The latter is a stable source of the dichlorobromomethide carbanion, which undergoes 1,4-addition with cyclic nitroalkenes and (E)-fum... Read More

Understanding anionic Chugaev elimination in pericyclic tetracene formation (2016)
Journal Article
Burroughs, L., Ritchie, J., & Woodward, S. (2016). Understanding anionic Chugaev elimination in pericyclic tetracene formation. Tetrahedron, 72(13), doi:10.1016/j.tet.2016.02.025. ISSN 0040-4020

The reaction pathway for the formation of tetracenes from the diols 1,2-C6H4(CHOHC≡CAr)2 , LiHDMS, CS2 and MeI has been modelled by computational methods at the CBS-QB3 level of theory. Comparison of PhCHOC(=S)YCCPh (Y = S- or SMe) indicates a sligh... Read More