All Outputs (5)

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy (2019)
Journal Article
Luveta, J., Parks, R. M., Heery, D. M., Cheung, K., & Johnston, S. J. (2020). Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy. Oncology and Therapy, 8, 1-11. https://doi.org/10.1007/s40487-019-00105-0

Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carci... Read More about Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT) (2019)
Journal Article
Robertson, J. F., Coleman, R. E., Cheung, K., Evans, A., Holcombe, C., Skene, A., …Gee, J. M. (2020). Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT). Clinical Cancer Research, 26(7), 1574-1585. https://doi.org/10.1158/1078-0432.CCR-19-3053

© 2020 American Association for Cancer Research Inc.. All rights reserved. Purpose: The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therape... Read More about Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).

Personalising Care in the Older Woman with Primary Breast Cancer (2019)
Journal Article
Parks, R. M., & Cheung, K. L. (2019). Personalising Care in the Older Woman with Primary Breast Cancer. Annals of the Academy of Medicine, Singapore, 48(11), 370-375

The incidence of breast cancer increases with age. Despite this, most research in the field is targeted at younger patients. Age-specific guidelines are not widely referred to and guidelines which allude to the older woman as an individual are based... Read More about Personalising Care in the Older Woman with Primary Breast Cancer.

Early-Stage Breast Cancer in Older Adults (2019)
Book Chapter
Cheung, K., Livi, L., & Brain, E. (2019). Early-Stage Breast Cancer in Older Adults. In M. Extermann (Ed.), Geriatric Oncology, 1-10. Springer. doi:10.1007/978-3-319-44870-1_33-1

Breast cancer is the most common cancer afflicting women worldwide. Its incidence peaks around 70, while mortality increases greatly after 75 years old. Given the competing risks on mortality with multimorbidities, geriatric assessment is a leitmotiv... Read More about Early-Stage Breast Cancer in Older Adults.

Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women (2019)
Journal Article
Syed, B. M., Green, A. R., Morgan, D. A., Ellis, I. O., & Cheung, K. (2019). Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women. Cancers, 11(2), 1-17. https://doi.org/10.3390/cancers11020149

Background: The role of liver kinase B1 (LKB1), a serine/threonine kinase, has been described in the development of PeutzJagher’s syndrome, where a proportion (~45%) of patients have developed breast cancer in their lifetime. Cell line studies have l... Read More about Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women.