Research Repository

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Infections up to 76 days after stroke increase disability and death (2017)
Journal Article
Learoyd, A., Woodhouse, L. J., Shaw, L., Sprigg, N., Bereczki, D., Berge, E., …Trueman, R. C. (in press). Infections up to 76 days after stroke increase disability and death. Translational Stroke Research, doi:10.1007/s12975-017-0553-3. ISSN 1868-4483

Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke... Read More

Hippocampal neural disinhibition causes attentional and memory deficits (2016)
Journal Article
McGarrity, S., Mason, R., Fone, K. C., Pezze, M. A., & Bast, T. (2017). Hippocampal neural disinhibition causes attentional and memory deficits. Cerebral Cortex, 27(9), doi:10.1093/cercor/bhw247. ISSN 1047-3211

Subconvulsive hippocampal neural disinhibition, that is reduced GABAergic inhibition, has been implicated in neuropsychiatric disorders characterized by attentional and memory deficits, including schizophrenia and age-related cognitive decline. Consi... Read More

Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats (2016)
Journal Article
Shortall, S. E., Green, A. R., Fone, K. C., & King, M. V. (2016). Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. Journal of Psychopharmacology, 30(7), doi:10.1177/0269881116650408. ISSN 0269-8811

Administration of caffeine with 3,4-methylenedioxymethamphetamine (MDMA) alters the pharmacological properties of MDMA in rats. The current study examined whether caffeine alters the behavioural and neurochemical effects of mephedrone, which has simi... Read More

The antimalarial drug quinine interferes with serotonin biosynthesis and action (2014)
Journal Article
Islahudin, F., Tindall, S. M., Mellor, I. R., Swift, K., Christensen, H. E., Fone, K. C., …Avery, S. V. (2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific Reports, 4(3618), doi:10.1038/srep03618. ISSN 2045-2322

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More

D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors (2013)
Journal Article
inhibition in mice lacking dopamine D2 receptors. Neuropsychopharmacology, 38(8), doi:10.1038/npp.2013.50. ISSN 0893-133X

Drugs that induce psychosis, such as D-amphetamine (AMP), and those that alleviate it, such as antipsychotics, are suggested to exert behavioral effects via dopamine receptor D2 (D2). All antipsychotic drugs are D2 antagonists, but D2 antagonism und... Read More