All Outputs (3)

The ‘dark matter’ of ubiquitin-mediated processes: opportunities and challenges in the identification of ubiquitin-binding domains (2019)
Journal Article
Radley, E., Long, J., Gough, K., & Layfield, R. (2019). The ‘dark matter’ of ubiquitin-mediated processes: opportunities and challenges in the identification of ubiquitin-binding domains. Biochemical Society Transactions, 47(6), 1949-1962. https://doi.org/10.1042/bst20190869

Ubiquitin modifications of target proteins act to localise, direct and specify a diverse range of cellular processes, many of which are biomedically relevant. To allow this diversity, ubiquitin modifications exhibit remarkable complexity, determined... Read More about The ‘dark matter’ of ubiquitin-mediated processes: opportunities and challenges in the identification of ubiquitin-binding domains.

Advances in the Production and Batch Reformatting of Phage Antibody Libraries (2019)
Journal Article
Reader, R. H., Workman, R. G., Maddison, B. C., & Gough, K. C. (2019). Advances in the Production and Batch Reformatting of Phage Antibody Libraries. Molecular Biotechnology, 61, 801-815. https://doi.org/10.1007/s12033-019-00207-0

Phage display antibody libraries have proven an invaluable resource for the isolation of diagnostic and potentially therapeutic antibodies, the latter usually being antibody fragments converted into IgG formats. Recent advances in the production of h... Read More about Advances in the Production and Batch Reformatting of Phage Antibody Libraries.

BSE infectivity survives burial for five years with only limited spread (2019)
Journal Article
Somerville, R. A., Fernie, K., Smith, A., Bishop, K., Maddison, B. C., Gough, K. C., …Gough, K. C. (2019). BSE infectivity survives burial for five years with only limited spread. Archives of Virology, 164(4), 1135–1145. https://doi.org/10.1007/s00705-019-04154-8

© 2019, The Author(s). The carcasses of animals infected with bovine spongiform encephalopathy (BSE), scrapie or chronic wasting disease (CWD) that remain in the environment (exposed or buried) may continue to act as reservoirs of infectivity. We co... Read More about BSE infectivity survives burial for five years with only limited spread.