All Outputs (6)

The chronic stages of bovine Fasciola hepatica are dominated by CD4 T-Cell exhaustion (2017)
Journal Article
Sachdev, D., Gough, K. C., & Flynn, R. J. (2017). The chronic stages of bovine Fasciola hepatica are dominated by CD4 T-Cell exhaustion. Frontiers in Immunology, 8, Article 1002. https://doi.org/10.3389/fimmu.2017.01002

Fasciola hepatica infection of ruminants leads to non-resolving chronic infection, as patency develops, there is switching to a TGF-? and IL-10 led response. Here, we explore the responses of CD4 T-cells within the major draining lymph nodes. We foun... Read More about The chronic stages of bovine Fasciola hepatica are dominated by CD4 T-Cell exhaustion.

The detection of great crested newts year round via environmental DNA analysis (2017)
Journal Article
Rees, H. C., Baker, C. A., Gardner, D. S., Maddison, B. C., & Gough, K. C. (2017). The detection of great crested newts year round via environmental DNA analysis. BMC Research Notes, 10(1), Article 327. https://doi.org/10.1186/s13104-017-2657-y

Objective Analysis of environmental DNA (eDNA) is a method that has been used for the detection of various species within water bodies. The great crested newt (Triturus cristatus) has a short eDNA survey season (mid-April to June). Here we investi... Read More about The detection of great crested newts year round via environmental DNA analysis.

Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro (2017)
Journal Article
Maddison, B. C., Workman, R. G., & Gough, K. C. (in press). Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro. Prion, 11(4), https://doi.org/10.1080/19336896.2017.1342919

Prion diseases are fatal and incurable neurodegenerative diseases of humans and animals. Despite years of research, no therapeutic agents have been developed that can effectively manage or reverse disease progression. Recently it has been identified... Read More about Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro.

An in vitro model for assessing effective scrapie decontamination (2017)
Journal Article
Gough, K. C., Baker, C., & Maddison, B. (2017). An in vitro model for assessing effective scrapie decontamination. Veterinary Microbiology, 207, https://doi.org/10.1016/j.vetmic.2017.05.018

Scrapie infectivity enters the environment via a multiplicity of routes from infected animals. Environmentally associated scrapie persists on farms when infected animals have been removed and is particularly resistant to disinfection. Infectivity wit... Read More about An in vitro model for assessing effective scrapie decontamination.

How is Europe positioned for a re-emergence of Schmallenberg virus? (2017)
Journal Article
Tarlinton, R., Gough, K., Maddison, B., Stavrou, A., Daly, J. M., Maddison, B. C., …Tarlinton, R. E. (2017). How is Europe positioned for a re-emergence of Schmallenberg virus?. Veterinary Journal, 230, 45-51. https://doi.org/10.1016/j.tvjl.2017.04.009

The Schmallenberg virus (SBV) caused a large scale epidemic in Europe from 2011–2013 infecting ruminants and causing fetal deformities after infection of pregnant animals. The main impacts of the virus were financial losses due to animal, meat and se... Read More about How is Europe positioned for a re-emergence of Schmallenberg virus?.

In vitro amplification of H-type atypical bovine spongiform encephalopathy by protein misfolding cyclic amplification (2017)
Journal Article
O'Connor, M., Bishop, K., Workman, R. G., Maddison, B. C., & Gough, K. C. (in press). In vitro amplification of H-type atypical bovine spongiform encephalopathy by protein misfolding cyclic amplification. Prion, 11(1), 54-64. https://doi.org/10.1080/19336896.2016.1259051

The in vitro amplification of prions by serial protein misfolding cyclic amplification has been shown to detect PrPSc to levels at least as sensitive as rodent bioassay but in a fraction of the time. Bovine spongiform encephalopathy is a zoonotic pri... Read More about In vitro amplification of H-type atypical bovine spongiform encephalopathy by protein misfolding cyclic amplification.