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A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid (2017)
Journal Article
Andrews, K. G., Faizova, R., & Denton, R. M. (in press). A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid. Nature Communications, 8, doi:10.1038/ncomms15913. ISSN 2041-1723

Amines are a fundamentally important class of biologically active compounds and the ability to manipulate their physicochemical properties through the introduction of fluorine is of paramount importance in medicinal chemistry. Current synthesis metho... Read More

A more critical role for silicon in the catalytic Staudinger amidation: silanes as non-innocent reductants (2017)
Journal Article
Andrews, K. G., & Denton, R. M. (2017). A more critical role for silicon in the catalytic Staudinger amidation: silanes as non-innocent reductants. Chemical Communications, 53(57), 7982-7985. doi:10.1039/C7CC03076B

Amides are ubiquitous in organic chemistry and occur in some of the most important natural and non-natural molecules such as peptides, pharmaceuticals and polymers.1 For this reason, amidation reactions are some of the most frequently carried out pro... Read More