Research Repository

See what's under the surface


Integrin-mediated interactions control macrophage polarization in 3D hydrogels (2017)
Journal Article
Cha, B., Shin, S. R., Leijten, J., Li, Y., Singh, S., Liu, J. C., …Khademhosseini, A. (in press). Integrin-mediated interactions control macrophage polarization in 3D hydrogels. Advanced Healthcare Materials, 6(21), doi:10.1002/adhm.201700289. ISSN 2192-2640

Adverse immune reactions prevent clinical translation of numerous implantable devices and materials. Although inflammation is an essential part of tissue regeneration, chronic inflammation ultimately leads to implant failure. In particular, macrophag... Read More

A paper-based in vitro model for on-chip investigation of the human respiratory system (2016)
Journal Article
Rahimi, R., Htwe, S. S., Ochoa, M., Donaldson, A., Zieger, M., Sood, R., …Ziaie, B. (in press). A paper-based in vitro model for on-chip investigation of the human respiratory system. Lab on a Chip, 16(22), doi:10.1039/C6LC00866F. ISSN 1473-0197

Culturing cells at the air–liquid interface (ALI) is essential for creating functional in vitro models of lung tissues. We present the use of direct-patterned laser-treated hydrophobic paper as an effective semi-permeable membrane, ideal for ALI cell... Read More

Photocrosslinkable gelatin hydrogel for epidermal tissue engineering (2015)
Journal Article
Zhao, X., Lang, Q., Yildirimer, L., Lin, Z. Y., Cui, W., Annabi, N., …Khademhosseini, A. (2016). Photocrosslinkable gelatin hydrogel for epidermal tissue engineering. Advanced Healthcare Materials, 5(1), doi:10.1002/adhm.201500005. ISSN 2192-2640

Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insu... Read More

Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2 (2013)
Journal Article
Roy, R., Usha, V., Kermani, A., Scott, D. J., Hyde, E. I., Besra, G. S., …Fütterer, K. (2013). Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2. ACS Chemical Biology, 8(10), doi:10.1021/cb400508k. ISSN 1554-8929

Recent evidence established that the cell envelope of Mycobacterium tuberculosis, the bacillus causing tuberculosis (TB), is coated by an α-glucan-containing capsule that has been implicated in persistence in a mouse infection model. As one of three... Read More