Research Repository

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Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2019). Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ, 364, doi:10.1136/bmj.k4810

Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy. Design: Two nested case-control studies. Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More

Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care (2018)
Journal Article
Vinogradova, Y., Coupland, C., Hill, T., & Hippisley-Cox, J. (2018). Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. BMJ, 362, doi:10.1136/bmj.k2505. ISSN 0959-8138

Objective: To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin. Design: Prospective open cohort study. Settin... Read More

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article
Coupland, C., Hill, T., Morriss, R., Moore, M., Arthur, A., & Hippisley-Cox, J. (2018). Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database. BMC Medicine, 16(1), doi:10.1186/s12916-018-1022-x. ISSN 1741-7015

Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. This study aimed to asse... Read More

Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study (2017)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2017). Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study. BMJ, 359, doi:10.1136/bmj.j5019. ISSN 0959-8138

Objectives: To derive and validate updated QDiabetes-2018 prediction algorithms to estimate the 10 year risk of type 2 diabetes in men and women, taking account of potential new risk factors, and to compare their performance with current approaches.... Read More

Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study (2017)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2017). Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study. BMJ, 358, doi:10.1136/bmj.j4208. ISSN 0959-8138

Objectives: To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission. Design: Prospective open... Read More

Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study (2017)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2017). Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study. BMJ, 357, doi:10.1136/bmj.j2497. ISSN 0959-8138

Objective: To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design: Cohort study. Setting: General practices in England providing data for the QResea... Read More

Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study (2017)
Journal Article
Hippisley-Cox, J., Coupland, C., & Brindle, P. (2017). Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ, 357, doi:10.1136/bmj.j2099. ISSN 0959-8138

Objectives: To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors. Design: Prospective open cohort study. Setting: General... Read More

Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care (2016)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2016). Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care. BMJ, 354(i3477), doi:10.1136/bmj.i3477. ISSN 0959-8138

Objective: To assess associations between risks of cardiovascular disease, heart failure, and all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly newer agents, including gliptins and thiazolidinediones (glita... Read More

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database (2016)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (in press). Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. BMJ, 353, doi:10.1136/bmj.i3305. ISSN 0959-8138

Objectives: To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting. Design: Prospective open cohort study. Setting: 664 general practices con... Read More

Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care (2016)
Journal Article
Hippisley-Cox, J., & Coupland, C. (in press). Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care. BMJ, 352, doi:10.1136/bmj.i1450. ISSN 0959-8138

Objective: To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed diabetes drugs, particularly newer agents including gliptins or glitazones (... Read More

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database (2016)
Journal Article
Coupland, C., Hill, T., Morriss, R. K., Moore, M., Arthur, A., & Hippisley-Cox, J. (2016). Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database. BMJ, 2016(352), doi:10.1136/bmj.i1350

Objective: To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depression. Design: Cohort study... Read More

The NHS Health Check in England: an evaluation of the first 4 years (2016)
Journal Article
Robson, J., Dostal, I., Sheikh, A., Eldridge, S., Madurasinghe, V., Griffiths, C., …Hippisley-Cox, J. (2016). The NHS Health Check in England: an evaluation of the first 4 years. BMJ Open, 6(1), doi:10.1136/bmjopen-2015-008840. ISSN 2044-6055

Objectives: To describe implementation of a new national preventive programme to reduce cardiovascular morbidity. Design: Observational study over 4 years (April 2009—March 2013). Setting: 655 general practices across England from the QResear... Read More

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database (2015)
Journal Article
Hill, T., Coupland, C., Morriss, R. K., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry, 15, doi:10.1186/s12888-015-0701-9. ISSN 1471-244X

Background: Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepres... Read More