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Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage (2017)
Journal Article
Watson, S. I., Chen, Y., Nguyen-Van-Tam, J. S., Myles, P. R., Venkatesan, S., Zambon, M., …Lilford, R. J. (2017). Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage. F1000Research, 5, https://doi.org/10.12688/f1000research.9414.2

Objectives: The stockpiling of neuraminidase inhibitor (NAI) antivirals as a defence against pandemic influenza is a significant public health policy decision that must be made despite a lack of conclusive evidence from randomised controlled trials r... Read More about Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage.

Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis (2017)
Journal Article
Lansbury, L. E., Smith, S., Beyer, W., Karamehic, E., Pasic-Juhas, E., Sikira, H., …Nguyen-Van-Tam, J. (in press). Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis. Vaccine, doi:10.1016/j.vaccine.2017.02.059

Background: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine effectiveness (VE) for adjuvanted and unadjuvanted vacc... Read More about Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis.

Impact of outpatient neuraminidase inhibitor treatment in patients infected with influenza A(H1N1)pdm09 at high risk of hospitalization: an Individual Participant Data (IPD) meta-analysis (2017)
Journal Article
Venkatesan, S., Myles, P. R., Leonardi-Bee, J., Muthuri, S. G., Al Masri, M., Andrews, N., …Nguyen-Van-Tam, J. S. (2017). Impact of outpatient neuraminidase inhibitor treatment in patients infected with influenza A(H1N1)pdm09 at high risk of hospitalization: an Individual Participant Data (IPD) meta-analysis. Clinical Infectious Diseases, 64(10), 1328-1334. https://doi.org/10.1093/cid/cix127

Background: While evidence exists to support the effectiveness of neuraminidase inhibitors (NAIs) in reducing mortality when given to hospitalized patients with A(H1N1)pdm09 virus infection, the impact of outpatient treatment on hospitalization has n... Read More about Impact of outpatient neuraminidase inhibitor treatment in patients infected with influenza A(H1N1)pdm09 at high risk of hospitalization: an Individual Participant Data (IPD) meta-analysis.

Middle East respiratory syndrome (2017)
Journal Article
Arabi, Y. M., Balkhy, H. H., Hayden, F. G., Bouchama, A., Luke, T., Baillie, J. K., …Fowler, R. A. (2017). Middle East respiratory syndrome. New England Journal of Medicine, 376(6), 584-594. https://doi.org/10.1056/NEJMsr1408795

The Middle East respiratory syndrome is caused by a coronavirus that was first identified in Saudi Arabia in 2012. Periodic outbreaks continue to occur in the Middle East and elsewhere. This report provides the latest information on MERS.

The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data (2016)
Journal Article
Nakafero, G., Sanders, R. D., Nguyen-Van-Tam, J. S., & Myles, P. R. (2016). The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data. Pharmacoepidemiology and Drug Safety, 25(11), 1263-1273. https://doi.org/10.1002/pds.4028

Purpose: Bacterial superinfections, including pneumonia, are frequent complications of influenza-like illness (ILI). Clinical and laboratory evidence suggests that benzodiazepines and Z-drugs may influence susceptibility to infections and mortality.... Read More about The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data.

Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review (2016)
Journal Article
Noso-RSV Study Group, , Higgins, J. P. T., French, C. E., McKenzie, B. C., Coope, C., Rajanaidu, S., …Beck, C. R. (2016). Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review. Influenza and Other Respiratory Viruses, 10(4), 268-290. https://doi.org/10.1111/irv.12379

Respiratory syncytial virus (RSV) causes a significant public health burden, and outbreaks among vulnerable patients in hospital settings are of particular concern. We reviewed published and unpublished literature from hospital settings to assess: (i... Read More about Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review.

Corticosteroids as adjunctive therapy in the treatment of influenza (2016)
Journal Article
Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Lim, W. S. (2016). Corticosteroids as adjunctive therapy in the treatment of influenza. Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD010406.pub2

Background: Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properti... Read More about Corticosteroids as adjunctive therapy in the treatment of influenza.

Cohort profile: the Flu Watch Study (2016)
Journal Article
Fragaszy, E. B., Warren-Gash, C., Wang, L., Copas, A., Dukes, O., Edmunds, W. J., …Hayward, A. C. (in press). Cohort profile: the Flu Watch Study. International Journal of Epidemiology, doi:10.1093/ije/dyv370

Influenza is a common, highly contagious respiratory virus which infects all age groups, causing a range of outcomes from asymptomatic infection and mild respiratory disease to severe respiratory disease and death.1 If infected, the adaptive immune s... Read More about Cohort profile: the Flu Watch Study.

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis (2016)
Journal Article
PRIDE Consortium Investigators, , Skręt-Magierło, J., Polack, F. P., Mayo-Montero, E., Leo, Y., Islam, Q. T., …Nguyen-Van-Tam, J. S. (2016). Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis. Influenza and Other Respiratory Viruses, 10(3), 192-204. https://doi.org/10.1111/irv.12363

BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H... Read More about Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.

Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort (2016)
Journal Article
the Combating Swine Influenza (COSI) Consortium, , the Flu Watch Group, , Fragaszy, E., Ishola, D. A., Brown, I. H., Enstone, J., …Wood, J. L. (2016). Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort. Influenza and Other Respiratory Viruses, 10(4), 291-300. https://doi.org/10.1111/irv.12364

Background: Pigs are mixing vessels for influenza viral reassortment but the extent of influenza transmission between swine and humans is not well understood. Objectives: To assess whether occupational exposure to pigs is a risk factor for human... Read More about Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.

The roles of transportation and transportation hubs in the propagation of influenza and coronaviruses: a systematic review (2016)
Journal Article
Browne, A., Ahmad, S. S., Beck, C. R., & Nguyen-Van-Tam, J. (in press). The roles of transportation and transportation hubs in the propagation of influenza and coronaviruses: a systematic review. Journal of Travel Medicine, 23(1), doi:10.1093/jtm/tav002

BACKGROUND: Respiratory viruses spread in humans across wide geographical areas in short periods of time, resulting in high levels of morbidity and mortality. We undertook a systematic review to assess the evidence that air, ground and sea mass trans... Read More about The roles of transportation and transportation hubs in the propagation of influenza and coronaviruses: a systematic review.

The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: Implications for infection prevention and control (2015)
Journal Article
Lim, W. S., Read, R. C., Killingley, B., Killingley, B., Greatorex, J., Digard, P., …Nguyen-Van-Tam, J. S. (2016). The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: Implications for infection prevention and control. Journal of Infection and Public Health, 9(3), 278-288. https://doi.org/10.1016/j.jiph.2015.10.009

In a multi-center, prospective, observational study over two influenza seasons, we sought to quantify and correlate the amount of virus recovered from the nares of infected subjects with that recovered from their immediate environment in community an... Read More about The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: Implications for infection prevention and control.

Influenza vaccines really work? Keeping apart the true from the false (2015)
Journal Article
Nguyen-Van-Tam, J., Gross, D., Sturkenboom, M., & Parrish-Sprowl, J. (2015). Influenza vaccines really work? Keeping apart the true from the false. Vaccine, 33(49), doi:10.1016/j.vaccine.2015.08.052

A yearly seasonal flu vaccine is the best preventive method we have against influenza at this time. Even then, vaccination adoption is hampered by on-going discussions about safety and effectiveness. In order to dot the I's and cross the T's at the f... Read More about Influenza vaccines really work? Keeping apart the true from the false.

Evaluation of the ‘Live Life Better Service’, a community-based weight management service, for morbidly obese patients (2015)
Journal Article
Wallace, D., Myles, P., Holt, R., & Van-Tam, J. N. (2016). Evaluation of the ‘Live Life Better Service’, a community-based weight management service, for morbidly obese patients. Journal of Public Health, 38(2), (e138-e149). doi:10.1093/pubmed/fdv103. ISSN 1741-3842

Background There is a limited evidence on the effectiveness of lifestyle interventions in achieving and maintaining a significant level of weight loss in morbidly obese patients. This study evaluated the impact on weight loss and psychological wel... Read More about Evaluation of the ‘Live Life Better Service’, a community-based weight management service, for morbidly obese patients.

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study (2015)
Journal Article
Millett, E. R. C., Hayward, A. C., Wang, L., Goonetilleke, N., Fragaszy, E. B., Bermingham, A., …McMichael, A. J. (2015). Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study. American Journal of Respiratory and Critical Care Medicine, 191(12), 1422-1431. https://doi.org/10.1164/rccm.201411-1988oc

Rationale: A high proportion of influenza infections are asymptomatic. Animal and human challenge studies and observational studies suggest T cells protect against disease among those infected, but the impact of T-cell immunity at the population leve... Read More about Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study.

Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink (2015)
Journal Article
Nakafero, G., Sanders, R. D., Nguyen-Van-Tam, J. S., & Myles, P. R. (2015). Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink. Pharmacoepidemiology and Drug Safety, 24(8), 793-802. https://doi.org/10.1002/pds.3799

Purpose: To investigate the association between the GABAergic drugs, benzodiazepines or zopiclone, and the occurrence of asthma exacerbations and subsequent mortality in a cohort of asthma patients. Methods: 105,747 patients without asthma exacerba... Read More about Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink.

From the Editor's desk (2015)
Journal Article
Nguyen-Van-Tam, J. S. (2015). From the Editor's desk. Influenza and Other Respiratory Viruses, 9(3), doi:10.1111/irv.12311

Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis (2015)
Journal Article
Aoyagi, Y., Beck, C. R., Dingwall, R., & Nguyen-Van-Tam, J. (2015). Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis. Influenza and Other Respiratory Viruses, 9(3), 120-130. https://doi.org/10.1111/irv.12310

To estimate the proportion of healthcare workers (HCWs) willing to work during an influenza pandemic and identify associated risk factors, we undertook a systematic review and meta-analysis compliant with PRISMA guidance. Databases and grey literatur... Read More about Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis.

Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation (2015)
Journal Article
Lim, W. S., Brittain, C., Duley, L., Edwards, S., Gordon, S., Montgomery, A., …Wootton, D. (2015). Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation. Health Technology Assessment, 19(16), doi:10.3310/hta19160

Background: There are no completed randomised trials of the use of corticosteroids in patients with severe influenza infection. Corticosteroid use in influenza is widespread, non-systematic and marked by controversy. A recent meta-analysis of observa... Read More about Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation.


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