All Outputs (7)

Human Adaptation of Ebola Virus during the West African Outbreak (2016)
Journal Article
Urbanowicz, R. A., McClure, C. P., Sakuntabhai, A., Sall, A. A., Kobinger, G., Müller, M. A., …Ball, J. K. (2016). Human Adaptation of Ebola Virus during the West African Outbreak. Cell, 167(4), 1079-1087.e5. https://doi.org/10.1016/j.cell.2016.10.013

The 2013–2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It began following the cross-species transmission of EBOV from an animal reservoir, most likely bats, into humans, with phylogenetic analysis revealing the cocircul... Read More about Human Adaptation of Ebola Virus during the West African Outbreak.

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin (2016)
Journal Article
Tawar, R. G., Heydmann, L., Bach, C., Schüttrumpf, J., Chavan, S., King, B. J., …Baumert, T. (2016). Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin. Hepatology, 64(5), 1495-1506. https://doi.org/10.1002/hep.28767

Hepatitis C virus (HCV)-induced end-stage liver disease is the major indication for liver transplantation (LT). However, reinfection of the liver graft is still common, especially in patients with detectable viral load at the time of LT. Limited data... Read More about Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin.

Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay (2016)
Journal Article
Urbanowicz, R. A., McClure, C. P., King, B., Mason, C. P., Ball, J. K., & Tarr, A. W. (2016). Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay. Journal of General Virology, 97(9), 2265-2279. https://doi.org/10.1099/jgv.0.000537

Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped viruses. This model has been extensively applied to the study of the hepatitis C virus (HCV) entry pathway, pre-clinical screening of antiviral antibodi... Read More about Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay.

Flexible and rapid construction of viral chimeras applied to hepatitis C virus (2016)
Journal Article
McClure, P. C., Urbanowicz, R. A., King, B. J., Cano-Crespo, S., Tarr, A. W., & Ball, J. K. (2016). Flexible and rapid construction of viral chimeras applied to hepatitis C virus. Journal of General Virology, 97(9), 2187-2193. https://doi.org/10.1099/jgv.0.000530

A novel and broadly applicable strategy combining site directed mutagenesis and DNA assembly for constructing seamless viral chimeras is described using Hepatitis C Virus as an exemplar. Full-length HCV genomic cloning cassettes, which contained flex... Read More about Flexible and rapid construction of viral chimeras applied to hepatitis C virus.

Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals (2016)
Journal Article
Ferns, R. B., Tarr, A. W., Hue, S., Urbanowicz, R. A., McClure, C. P., Gilson, R., …Pillay, D. (2016). Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals. Virology, 492, 213-224. https://doi.org/10.1016/j.virol.2016.02.003

HIV-1 infected patients who acquire HCV infection have higher rates of chronicity and liver disease progression than patients with HCV mono-infection. Understanding early events in this pathogenic process is important. We applied single genome sequen... Read More about Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals.

Discovery of novel alphacoronaviruses in European rodents and shrews (2016)
Journal Article
Tsoleridis, T., Onianwa, O., Horncastle, E., Dayman, E., Zhu, M., Danjittrong, T., …McClure, P. (2016). Discovery of novel alphacoronaviruses in European rodents and shrews. Viruses, 8(3), Article 84. https://doi.org/10.3390/v8030084

Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex ar... Read More about Discovery of novel alphacoronaviruses in European rodents and shrews.

Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb (2016)
Journal Article
Paciello, R., Urbanowicz, R. A., Riccio, G., Sasso, E., McClure, C. P., Zambrano, N., …De Lorenzo, C. (2016). Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb. Journal of General Virology, 97(1), 82-94. https://doi.org/10.1099/jgv.0.000330

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver carcinoma and new therapies based on novel targets are needed. The tight junction protein claudin 1 (CLDN-1) is essential for HCV cell entry and spread, and anti-CLDN-1 rat and m... Read More about Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb.