Skip to main content

Research Repository

Advanced Search

All Outputs (3)

A supervised adverse drug reaction signalling framework imitating Bradford Hill’s causality considerations (2015)
Journal Article
Reps, J. M., Garibaldi, J. M., Aickelin, U., Gibson, J. E., & Hubbard, R. B. (2015). A supervised adverse drug reaction signalling framework imitating Bradford Hill’s causality considerations. Journal of Biomedical Informatics, 56, https://doi.org/10.1016/j.jbi.2015.06.011

Big longitudinal observational medical data potentially hold a wealth of information and have been recognised as potential sources for gaining new drug safety knowledge. Unfortunately there are many complexities and underlying issues when analysing l... Read More about A supervised adverse drug reaction signalling framework imitating Bradford Hill’s causality considerations.

Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs (2014)
Journal Article
Reps, J., M. Garibaldi, J., Aickelin, U., Soria, D., E. Gibson, J., & B. Hubbard, R. (2014). Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs. Drug Safety, 37(3), 163-170. https://doi.org/10.1007/s40264-014-0137-z

Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness. The main reason this safety knowledge is lacking is due to ethical restrictions... Read More about Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs.

A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery (2013)
Journal Article
Reps, J. M., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. (2014). A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery. IEEE Journal of Biomedical and Health Informatics, 18(2), 537-547. https://doi.org/10.1109/JBHI.2013.2281505

Drugs are frequently prescribed to patients with the aim of improving each patient's medical state, but an unfortunate consequence of most prescription drugs is the occurrence of undesirable side effects. Side effects that occur in more than one in a... Read More about A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery.