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All Outputs (6)

A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance (2015)
Journal Article
Urbanowicz, R. A., McClure, P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., …Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of Virology, 90(7), 3288-3301. https://doi.org/10.1128/JVI.02700-15

Despite significant advances in the treatment of hepatitis C virus (HCV) infection, the need to develop preventative vaccines remains. Identification of the best vaccine candidates and evaluation of their performance in preclinical and clinical devel... Read More about A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance.

An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule (2015)
Journal Article
Nigro, E., Colavita, I., Sarnataro, D., Scudiero, O., Zambrano, G., Granata, V., …Pessi, A. (2015). An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule. Scientific Reports, 5, Article 18450. https://doi.org/10.1038/srep18450

Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated “γ-core motif”. We reasoned that for each HDPs evolved from an ancestral γ-core,... Read More about An ancestral host defence peptide within human beta-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice (2015)
Journal Article
Vercauteren, K., Brown, R. J., Mesalam, A. A., Doerrbecker, J., Bhuju, S., Geffers, R., …Meuleman, P. (2016). Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice. Gut, 65(12), https://doi.org/10.1136/gutjnl-2014-309045

Objective: Direct-acting antivirals (DAAs) inhibit hepatitis C virus (HCV) infection by targeting viral proteins that play essential roles in the replication process. However, selection of resistance-associated variants (RAVs) during DAA therapy has... Read More about Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice.

Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces (2015)
Journal Article
Hakami, A. R., Ball, J. K., & Tarr, A. W. (2015). Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces. Journal of Virological Methods, 221, 1-8. https://doi.org/10.1016/j.jviromet.2015.04.023

© 2015 Elsevier B.V. Phage-displayed random peptide libraries are widely used for identifying peptide interactions with proteins and other substrates. Selection of peptide ligands involves iterative rounds of affinity enrichment. The binding properti... Read More about Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces.

Structural flexibility of a conserved antigenic region in Hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies (2015)
Journal Article
Meola, A., Tarr, A. V., England, P., Meredith, L. W., McClure, P., Foung, S. K., …Krey, T. (2015). Structural flexibility of a conserved antigenic region in Hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies. Journal of Virology, 89(4), 2170-2181. https://doi.org/10.1128/JVI.02190-14

Neutralizing antibodies (NAbs) targeting glycoprotein E2 are important for the control of hepatitis C virus (HCV) infection. One conserved antigenic site (amino acids 412 to 423) is disordered in the reported E2 structure, but a synthetic peptide mim... Read More about Structural flexibility of a conserved antigenic region in Hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies.