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All Outputs (6)

Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry (2014)
Journal Article
Hamed, M. R., Brown, R. J., Zothner, C., Urbanowicz, R. A., Mason, C. P., Krarup, A., …Tarr, A. W. (2014). Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry. Journal of Innate Immunity, 6(5), 676-684. https://doi.org/10.1159/000362209

L-ficolin is a soluble pattern recognition molecule expressed by the liver that contributes to innate immune defense against microorganisms. It is well described that binding of L-ficolin to specific pathogen-associated molecular patterns activates t... Read More about Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry.

The past, present and future of neutralizing antibodies for hepatitis C virus (2014)
Journal Article
Ball, J. K., Tarr, A. W., & McKeating, J. A. (2014). The past, present and future of neutralizing antibodies for hepatitis C virus. Antiviral Research, 105(1), 100-111. https://doi.org/10.1016/j.antiviral.2014.02.013

Hepatitis C virus (HCV) is a major cause of liver disease and hepatocellular carcinoma worldwide. HCV establishes a chronic infection in the majority of cases. However, some individuals clear the virus, demonstrating a protective role for the host im... Read More about The past, present and future of neutralizing antibodies for hepatitis C virus.

Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution (2014)
Journal Article
Brown, R. J., Koutsoudakisu, G., Urbanowicz, R. A., Mirza, D., Ginkel, C., Riebesehl, N., …Ball, J. K. (2014). Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution. Journal of Virology, 88(1), 667-678. https://doi.org/10.1128/JVI.01745-13

Serine is encoded by two divergent codon types, UCN and AGY, which are not interchangeable by a single nucleotide substitution. Switching between codon types therefore occurs via intermediates (threonine or cysteine) or via simultaneous tandem substi... Read More about Analysis of Serine Codon Conservation Reveals Diverse Phenotypic Constraints on Hepatitis C Virus Glycoprotein Evolution.

B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins (2014)
Journal Article
Ng, P. P., BALL, J., Kuo, C., Wang, S., Einav, S., Arcaini, L., …Levy, S. (2014). B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins. Blood, 123(10), 1512–1515. https://doi.org/10.1182/blood-2013-10-532895

Chronic hepatitis C virus (HCV) infection has been implicated in the induction and maintenance of B-cell lymphomas. The strongest evidence for this derives from clinical observations of tumor regressions upon antiviral treatments. Here we used multip... Read More about B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins.

Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies (2014)
Journal Article
Edwards, V. C., McClure, P., Brown, R. J., Thompson, E., Irving, W. L., & Ball, J. K. (in press). Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies. Journal of General Virology, 95(1), https://doi.org/10.1099/vir.0.057828-0

Sequence analysis is used to define the molecular epidemiology and evolution of the hepatitis C virus. Whilst most studies have shown that individual patients harbour viruses that are derived from a limited number of highly related strains, some rece... Read More about Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies.