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All Outputs (22)

Methodology for Digital Transformation: A Continuous Improvement Approach (2023)
Conference Proceeding
Hernández Oliver, K., Martínez-Arellano, G., & Segal, J. (2023). Methodology for Digital Transformation: A Continuous Improvement Approach. In 1st Workshop on Low-Cost Digital Solutions for Industrial Automation

Digital technologies have the potential to significantly transform the manufacturing industry by achieving improvements in productivity, quality and sustainability. Despite this, the uptake is relatively low as companies face a number of challenges i... Read More about Methodology for Digital Transformation: A Continuous Improvement Approach.

Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study (2023)
Conference Proceeding
Hernández Oliver, K. H., Martínez-Arellano, G., & Segal, J. (2023). Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study. In 1st Workshop on Low-Cost Digital Solutions for Industrial Automation

The use of digital technologies around the world has increased considerably, modifying the way in which daily activities are conducted. The manufacturing sector is no exception. Over the last decade, digital technologies have become a key element for... Read More about Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study.

Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma (2020)
Journal Article
Sabri, A. H., Cater, Z., Gurnani, P., Ogilvie, J., Segal, J., Scurr, D. J., & Marlow, M. (2020). Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma. International Journal of Pharmaceutics, 589, Article 119808. https://doi.org/10.1016/j.ijpharm.2020.119808

Despite being one of the most efficacious drugs used in the treatment of basal cell carcinoma (BCC), imiquimod has limited cutaneous permeation. The current work presents the development of polyvinylpyrrolidone-co-vinyl acetate (PVPVA) microneedles l... Read More about Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma.

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules (2020)
Journal Article
Sabri, A., Ogilvie, J., McKenna, J., Segal, J., Scurr, D., & Marlow, M. (2020). Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules. Molecular Pharmaceutics, 17(8), 2925–2937. https://doi.org/10.1021/acs.molpharmaceut.0c00347

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in humans. One of the most efficacious drugs used in the management of BCC is the immunomodulator, imiquimod. However, imiquimod has physiochemical properties that limit its permeatio... Read More about Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules.

Characterisation of mechanical insertion of commercial microneedles (2020)
Journal Article
Sabri, A. H., Cater, Z., Ogilvie, J., Scurr, D. J., Marlow, M., & Segal, J. (2020). Characterisation of mechanical insertion of commercial microneedles. Journal of Drug Delivery Science and Technology, 58, https://doi.org/10.1016/j.jddst.2020.101766

The protection provided by the human skin is mostly attributed to the stratum corneum. However, this barrier also limits the range of molecules that can be delivered into and across the skin. One of the methods to overcome this physiological barrier... Read More about Characterisation of mechanical insertion of commercial microneedles.

The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells (2020)
Journal Article
Ruiter, F. A., Sidney, L. E., Kiick, K. L., Segal, J. I., Alexander, C., & Rose, F. R. A. J. (2020). The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells. Biomaterials Science, 8(9), 2611-2626. https://doi.org/10.1039/c9bm01965k

Current cell expansion methods for tissue engineering and regenerative medicine applications rely on the use of enzymatic digestion passaging and 2D platforms. However, this enzymatic treatment significantly reduces cell quality, due to the destructi... Read More about The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells.

Multi-material 3D bioprinting of porous constructs for cartilage regeneration (2019)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2020). Multi-material 3D bioprinting of porous constructs for cartilage regeneration. Materials Science and Engineering: C, 109, https://doi.org/10.1016/j.msec.2019.110578

© 2020 Elsevier B.V. The current gold standard for nasal reconstruction after rhinectomy or severe trauma includes transposition of autologous cartilage grafts in conjunction with coverage using an autologous skin flap. Harvesting autologous cartilag... Read More about Multi-material 3D bioprinting of porous constructs for cartilage regeneration.

Improving children’s and their visitors’ hand hygiene compliance (2019)
Journal Article
Lary, D., Calvert, A., Nerlich, B., Segal, J., Vaughan, N., Randle, J., & Hardie, K. (2020). Improving children’s and their visitors’ hand hygiene compliance. Journal of Infection Prevention, 21(2), 60-67. https://doi.org/10.1177/1757177419892065

Background: Numerous interventions have tried to improve healthcare workers' hand hygiene compliance, however little attention has been paid to children's and their visitors’ compliance. Aim: To increase children’s and visitors’ compliance using in... Read More about Improving children’s and their visitors’ hand hygiene compliance.

VOLCO: a predictive model for 3D printed microarchitecture (2018)
Journal Article
Gleadall, A., Ashcroft, I., & Segal, J. (in press). VOLCO: a predictive model for 3D printed microarchitecture. Additive Manufacturing, 21, https://doi.org/10.1016/j.addma.2018.04.004

Extrusion-based 3D printing is widely used for porous scaffolds in which polymer filaments are extruded in the form of log-pile structures. These structures are typically designed with the assumption that filaments have a continuous cylindrical profi... Read More about VOLCO: a predictive model for 3D printed microarchitecture.

Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation (2018)
Journal Article
Citossi, F., Smith, T., Lee, J. B., Segal, J., Gershkovich, P., Stocks, M. J., …Marlow, M. (in press). Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation. Molecular Pharmaceutics, 15(4), https://doi.org/10.1021/acs.molpharmaceut.7b01106

Low molecular weight gelators (LMWGs) of chemotherapeutic drugs represent a valid alternative to the existing poly-mer-based formulations used for targeted delivery of anticancer drugs. Herein we report the design and development of novel self-assemb... Read More about Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation.

A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies (2017)
Journal Article
Ruiter, F. A. A., Alexander, C., Rose, F. R., & Segal, J. (2017). A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies. Biomedical Materials, 12(5), Article 055009. https://doi.org/10.1088/1748-605X/aa7b54

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple... Read More about A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses (2017)
Journal Article
Stuart, B. W., Gimeno-Fabra, M., Segal, J., Ahmed, I., & Grant, D. M. (2017). Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses. Applied Surface Science, 416, 605-617. https://doi.org/10.1016/j.apsusc.2017.04.110

Here we show the deposition of 2.7 μm thick phosphate based glass films produced by magnetron sputtering, followed by post heat treatments at 500 °C. Variations in degradation properties pre and post heat treatment were attributed to the formation of... Read More about Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses.

Cyclic pressure on compression-moulded bioresorbable phosphate glass fibre reinforced composites (2016)
Journal Article
Barrera Betanzos, F., Gimeno-Fabra, M., Segal, J., Grant, D., & Ahmed, I. (2016). Cyclic pressure on compression-moulded bioresorbable phosphate glass fibre reinforced composites. Materials and Design, 100, https://doi.org/10.1016/j.matdes.2016.03.108

The use of thermoplastic composites based on poly(lactic) acid and phosphate glass fibres over metallic alloys for clinical restorative treatment is highly beneficial due to their biocompatibility and biodegradability. However, difficulties in achiev... Read More about Cyclic pressure on compression-moulded bioresorbable phosphate glass fibre reinforced composites.

A decision support methodology for embodiment design and process chain selection for hybrid manufacturing platforms (2016)
Journal Article
Gleadal, A., Vladov, N., Segal, J., Ratchev, S., Plasch, M., Kimmig, D., & Dickerhof, M. (2016). A decision support methodology for embodiment design and process chain selection for hybrid manufacturing platforms. International Journal of Advanced Manufacturing Technology, 87(1-4), 553-569. doi:10.1007/s00170-016-8514-7

This paper presents a methodology for the transformation of a product concept into a detailed design and manufacturing process chain for hybrid manufacturing platforms. Hybrid platforms offer new capabilities and opportunities for product design. How... Read More about A decision support methodology for embodiment design and process chain selection for hybrid manufacturing platforms.

Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing (2016)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2016). Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing. Biofabrication, 8(1), Article 015016. https://doi.org/10.1088/1758-5090/8/1/015016

© 2016 IOP Publishing Ltd. 3D printing is of great interest for tissue engineering scaffolds due to the ability to form complex geometries and control internal structures, including porosity and pore size. The porous structure of scaffolds plays an i... Read More about Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing.

A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes (2015)
Journal Article
Hourd, P., Medcalf, N., Segal, J., & Williams, D. J. (2015). A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes. Regenerative Medicine, 10(7), doi:10.2217/rme.15.52

Computer-aided 3D printing approaches to the industrial production of customized 3D functional living constructs for restoration of tissue and organ function face significant regulatory challenges. Using the manufacture of a customized, 3D-bioprinted... Read More about A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes.

Degradation and Characterization of Resorbable Phosphate-Based Glass Thin-Film Coatings Applied by Radio-Frequency Magnetron Sputtering (2015)
Journal Article
Stuart, B. W., Stuart, B., Gimeno-Fabra, M., Segal, J., Ahmed, I., & Grant, D. M. (2015). Degradation and Characterization of Resorbable Phosphate-Based Glass Thin-Film Coatings Applied by Radio-Frequency Magnetron Sputtering. ACS Applied Materials and Interfaces, 7(49), 27362-27372. https://doi.org/10.1021/acsami.5b08957

Quinternary phosphate-based glasses of up to 2.67 ?m, deposited by radio-frequency magnetron sputtering, were degraded in distilled water and phosphate-buffered saline (PBS) to investigate their degradation characteristics. Magnetron- sputtered coati... Read More about Degradation and Characterization of Resorbable Phosphate-Based Glass Thin-Film Coatings Applied by Radio-Frequency Magnetron Sputtering.

Apparent beam size definition of focused ion beams based on scanning electron microscopy images of nanodots (2015)
Journal Article
Vladov, N., Segal, J., & Ratchev, S. (2015). Apparent beam size definition of focused ion beams based on scanning electron microscopy images of nanodots. Journal of Vacuum Science and Technology B Microelectronics and Nanometer Structures, 33, Article 041803. https://doi.org/10.1116/1.4926388

In this paper the new term apparent beam size of Focused Ion Beam (FIB) is introduced and an original method of its evaluation is demonstrated. Traditional methods of measuring the beam size, like the knife edge method, provide information about the... Read More about Apparent beam size definition of focused ion beams based on scanning electron microscopy images of nanodots.

Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation (2014)
Journal Article
Win Naing, M., Gibson, D. A., Hourd, P., Gomez, S. G., Horton, R. B., Segal, J., & Williams, D. J. (2015). Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation. Cytotherapy, 17(1), 58-67. doi:10.1016/j.jcyt.2014.09.003

Background aims: With the rising use of umbilical cord blood (UCB) as an alternative source of hematopoietic stem cells, storage inventories of UCB have grown, giving rise to genetically diverse inventories globally. In the absence of reliable marker... Read More about Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation.