All Outputs (4)

High incidence of antibiotic resistance amongst isolates of Helicobacter pylori collected in Nottingham, UK, between 2001 and 2018 (2023)
Journal Article
Garvey, E., Rhead, J., Suffian, S., Whiley, D., Mahmood, F., Bakshi, N., …Robinson, K. (2023). High incidence of antibiotic resistance amongst isolates of Helicobacter pylori collected in Nottingham, UK, between 2001 and 2018. Journal of Medical Microbiology, 72(11), Article 001776. https://doi.org/10.1099/jmm.0.001776

Introduction. Helicobacter pylori is the leading cause of peptic ulcers and gastric cancer. The most common treatment regimens use combinations of two or three antibiotics and a proton pump inhibitor (PPI) to suppress stomach acid. The World Health O... Read More about High incidence of antibiotic resistance amongst isolates of Helicobacter pylori collected in Nottingham, UK, between 2001 and 2018.

Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells (2016)
Journal Article
Hussain, K., Letley, D. P., Greenaway, A. B., Kenefeck, R., Winter, J. A., Tomlinson, W., …Robinson, K. (2016). Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells. Frontiers in Immunology, 7, Article 71. https://doi.org/10.3389/fimmu.2016.00071

© 2016 Hussain, Letley, Greenaway, Kenefeck, Winter, Tomlinson, Rhead, Staples, Kaneko, Atherton and Robinson. Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1),... Read More about Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells.

A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach (2014)
Journal Article
Winter, J., Letley, D., Cook, K., Rhead, J., Zaitoun, A., Ingram, R., …Atherton, J. (2014). A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach. Journal of Infectious Diseases, 210(6), 954–963. https://doi.org/10.1093/infdis/jiu154

Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and... Read More about A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach.

Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells (2014)
Journal Article
Winter, J., Letley, D., Rhead, J., Atherton, J., & Robinson, K. (2014). Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells. Infection and Immunity, 82(4), 1372-1381. https://doi.org/10.1128/iai.01443-13

Persistent Helicobacter pylori infection induces chronic inflammation in the human gastric mucosa, which is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma. It has been postulated that secretion of immuno... Read More about Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells.