Skip to main content

Research Repository

Advanced Search

All Outputs (29)

Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016 (2022)
Journal Article
Scutt, P., Ban, L., Card, T., Crooks, C. J., Guha, N., West, J., & Morling, J. R. (2022). Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016. BMJ Open, 12(9), e058967. https://doi.org/10.1136/bmjopen-2021-058967

OBJECTIVE: We aimed to determine (1) the temporal trends of liver enzyme testing in UK general practice and (2) how these vary among different subgroups at risk of chronic liver disease (CLD). DESIGN: Retrospective cohort study. SETTING: UK primary c... Read More about Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016.

Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units (2022)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units. QJM: An International Journal of Medicine, 116(1), 63-67. https://doi.org/10.1093/qjmed/hcac218

Summary Background Pulse oximeters are widely used to monitor blood oxygen saturations, although concerns exist that they are less accurate in individuals with pigmented skin. Aims This study aimed to determine if patients with pigmented skin were mo... Read More about Differential pulse oximetry readings between ethnic groups and delayed transfer to intensive care units.

Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (2022)
Journal Article
Crooks, C. J., West, J., Fogarty, A., Morling, J. R., Grainge, M. J., Gonem, S., …Card, T. R. (2022). Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2. American Journal of Epidemiology, 191(11), 1944-1953. https://doi.org/10.1093/aje/kwac126

We compared the performance of prognostic tools for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using parameters fitted either at the time of hospital admission or across all time points of an admission. This cohort study used clinic... Read More about Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2.

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: Results from a genome-wide case-control study (2022)
Journal Article
Buch, S., Innes, H., Lutz, P. L., Nischalke, H. D., Marquardt, J. U., Fischer, J., …Stickel, F. (2022). Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: Results from a genome-wide case-control study. Gut, https://doi.org/10.1136/gutjnl-2022-327196

Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence... Read More about Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: Results from a genome-wide case-control study.

Alcohol-related liver disease mortality and missed opportunities in secondary care: A United Kingdom retrospective observational study (2022)
Journal Article
Subhani, M., Elleray, R., Bethea, J., Morling, J. R., & Ryder, S. D. (2022). Alcohol-related liver disease mortality and missed opportunities in secondary care: A United Kingdom retrospective observational study. Drug and Alcohol Review, 41(6), 1331-1340. https://doi.org/10.1111/dar.13482

Introduction: Alcohol-related liver disease (ARLD) is a preventable cause of mortality. Historical epidemiological studies on ARLD often lack a detailed linked assessment of health-related contacts prior to death which limits understanding of opportu... Read More about Alcohol-related liver disease mortality and missed opportunities in secondary care: A United Kingdom retrospective observational study.

Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection (2022)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. (2022). Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection. Clinical Medicine, 22(3), 192-196. https://doi.org/10.7861/clinmed.2021-0603

Objective To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age. Methods Participants were patients admitted to hospital with SARS-CoV-2 infection. For each partici... Read More about Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection.

Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis (2022)
Journal Article
Subhani, M., Sheth, A., Ahmed, J., Wijayasiri, P., Gardezi, S. A., Enki, D., …Aravinthan, A. D. (2022). Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis. Thrombosis Research, 215, 19-29. https://doi.org/10.1016/j.thromres.2022.05.004

Background and Aims: Historically, bleeding was thought to be a frequent and fatal complication of liver disease. However, thrombosis due to coagulation disorders in cirrhosis remains a real risk. We aim to systematically analyse published articles t... Read More about Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis.

Characteristics of alcohol recovery narratives: Systematic review and narrative synthesis (2022)
Journal Article
Subhani, M., Talat, U., Knight, H., Morling, J. R., Jones, K. A., Aithal, G. P., …Rennick-Egglestone, S. (2022). Characteristics of alcohol recovery narratives: Systematic review and narrative synthesis. PLoS ONE, 17(5), Article e0268034. https://doi.org/10.1371/journal.pone.0268034

Background and aims Narratives of recovery from alcohol misuse have been analysed in a range of research studies. This paper aims to produce a conceptual framework describing the characteristics of alcohol misuse recovery narratives that are in the r... Read More about Characteristics of alcohol recovery narratives: Systematic review and narrative synthesis.

Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: An observational study (2022)
Journal Article
Hill, T. A., Crooks, C. J., West, J., & Morling, J. R. (2022). Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: An observational study. BMJ Open Gastroenterology, 9(1), Article e000885. https://doi.org/10.1136/bmjgast-2022-000885

Objective If non-invasive markers of liver fibrosis were recorded frequently enough in clinical practice, it might be feasible to use them for opportunistic community screening for liver disease. We aimed to determine their current pattern of usage i... Read More about Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: An observational study.

Performance of routine risk scores for predicting cirrhosis-related morbidity in the community (2022)
Journal Article
Innes, H., Morling, J. R., Buch, S., Hamill, V., Stickel, F., & Guha, I. N. (2022). Performance of routine risk scores for predicting cirrhosis-related morbidity in the community. Journal of Hepatology, 77(2), 365-376. https://doi.org/10.1016/j.jhep.2022.02.022

BACKGROUND & AIMS: Models predicting an individual’s ten-year risk of cirrhosis complications have not been developed for a community setting. Our objectives were to assess the performance of existing risk scores – both with and without genetic data... Read More about Performance of routine risk scores for predicting cirrhosis-related morbidity in the community.

Health Technology Adoption in Liver Disease: Innovative Use of Data Science Solutions for Early Disease Detection (2022)
Journal Article
Bennett, L., Purssell, H., Street, O., Piper Hanley, K., Morling, J. R., Hanley, N. A., …ID-LIVER Consortium. (2022). Health Technology Adoption in Liver Disease: Innovative Use of Data Science Solutions for Early Disease Detection. Frontiers in Digital Health, 4, Article 737729. https://doi.org/10.3389/fdgth.2022.737729

Chronic liver disease (CLD) is an ignored epidemic. Premature mortality is considerable and in the United Kingdom (UK) liver disease is in the top three for inequitable healthcare alongside heart and respiratory disease. Fifty percentage of patients... Read More about Health Technology Adoption in Liver Disease: Innovative Use of Data Science Solutions for Early Disease Detection.

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis (2021)
Journal Article
Innes, H., Nischalke, H. D., Guha, I. N., Weiss, K. H., Irving, W., Gotthardt, D., …Buch, S. (2022). The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis. Hepatology Communications, 6(5), 1213-1226. https://doi.org/10.1002/hep4.1886

The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E (APOE), rs2642438 in mitochondrial amidoxime reducing component 1 (M... Read More about The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis.

Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial (2021)
Journal Article
Subhani, M., Jones, K. A., Sprange, K., Rennick-Egglestone, S., Knight, H., Morling, J. R., …Ryder, S. D. (2021). Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial. BMJ Open, 11(11), Article e054954. https://doi.org/10.1136/bmjopen-2021-054954

Introduction Heavy drinkers in contact with alcohol services do not routinely have access to testing to establish the severity of potential liver disease. Transient elastography by FibroScan can provide this information. A recent systematic review su... Read More about Does knowledge of liver fibrosis affect high-risk drinking behaviour (KLIFAD)? protocol for a feasibility randomised controlled trial.

Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity (2021)
Journal Article
Innes, H., Crooks, C. J., Aspinall, E., Card, T. R., Hamill, V., Dillon, J., …Morling, J. R. (2022). Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity. Hepatology, 75(2), 369-378. https://doi.org/10.1002/hep.32123

Background and Aims: It is thought that alcohol intake and body mass index (BMI) interact supra-additively to modulate the risk of cirrhosis, but evidence for this phenomenon is limited. We investigated the interrelationship between alcohol and BMI o... Read More about Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity.

The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study (2021)
Journal Article
Subhani, M., Sheth, A., Unitt, S., Aithal, G. P., Ryder, S. D., & Morling, J. R. (2022). The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study. Alcohol and Alcoholism, 57(2), 203-210. https://doi.org/10.1093/alcalc/agab059

Aim: To assess the impact of Covid-19 on alcohol use disorders (AUD) and the role of universal alcohol screening (UAS) in an inpatient setting. Methods: Retrospective cohorts were defined as pre-pandemic and pandemic admitted to Nottingham University... Read More about The Effect of Covid-19 on Alcohol Use Disorder and the Role of Universal Alcohol Screening in an Inpatient Setting: A Retrospective Cohort Control Study.

Addition of hyaluronic acid to the FIB-4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in Type 2 diabetes: The Edinburgh Type 2 Diabetes Study (2021)
Journal Article
Grecian, S. M., McLachlan, S., Fallowfield, J. A., Hayes, P. C., Guha, I. N., Morling, J. R., …Strachan, M. W. (2021). Addition of hyaluronic acid to the FIB-4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in Type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Obesity Science and Practice, 7(5), 497-508. https://doi.org/10.1002/osp4.484

Background: Type 2 diabetes is associated with increased risk of progression to cirrhosis and hepatocellular carcinoma (HCC) in people with chronic liver diseases, particularly non-alcoholic fatty liver disease (NAFLD). However, the absolute risk of... Read More about Addition of hyaluronic acid to the FIB-4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in Type 2 diabetes: The Edinburgh Type 2 Diabetes Study.

Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation (2021)
Journal Article
Bailey, J. A., Weller, J., Chapman, C., Ford, A., Hardy, K., Oliver, S., …Banerjea, A. (2021). Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation. BJS Open, 5(2), Article zraa056. https://doi.org/10.1093/bjsopen/zraa056

Background A novel pathway incorporating faecal immunochemical testing (FIT) for rapid colorectal cancer diagnosis (RCCD) was introduced in 2017. This paper reports on the service evaluation after 2 years of pathway implementation. Methods The R... Read More about Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation.

Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis (2021)
Journal Article
Subhani, M., Knight, H., Ryder, S., & Morling, J. R. (2021). Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis. Alcohol and Alcoholism, 56(2), 185–200. https://doi.org/10.1093/alcalc/agaa143

Background: Alcohol dependence affects over 240 million people worldwide and attributed to 3 million deaths annually. Early identification and intervention are key to prevent harm. We aim to systematically review literature on the effectiveness of ad... Read More about Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis.

Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer (2020)
Journal Article
Chapman, C. J., Banerjea, A., Humes, D. J., Allen, J., Oliver, S., Ford, A., …Morling, J. R. (2021). Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer. Clinical Chemistry and Laboratory Medicine, 59(4), 721-728. https://doi.org/10.1515/cclm-2020-1170

Objectives: Currently NICE recommends the use of faecal immunochemical test (FIT) at faecal haemoglobin concentrations (f-Hb) of 10 μg Hb/g faeces to stratify for colorectal cancer (CRC) risk in symptomatic populations. This f-Hb cut-off is advised a... Read More about Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer.