Skip to main content

Research Repository

Advanced Search

All Outputs (14)

The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2018)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2018). The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 8, Article 15915. https://doi.org/10.1038/s41598-018-34315-9

Synthetic beta-adrenergic agonists (BA) have broad biomedical and agricultural application for increasing lean body mass, yet a poor understanding of the biology underpinning these agents is limiting further drug discovery potential. Growing female p... Read More about The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice (2018)
Journal Article
Watkins, A. J., Dias, I., Tsuro, H., Allen, D., Emes, R. D., Moreton, J., …Sinclair, K. D. (2018). Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice. Proceedings of the National Academy of Sciences, 115(40), 10064-10069. https://doi.org/10.1073/pnas.1806333115

© 2018 National Academy of Sciences. All rights reserved. The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesi... Read More about Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice.

Identification of stable reference genes for quantitative PCR in koalas (2018)
Journal Article
Sarker, N., Fabijan, J., Emes, R. D., Hemmatzadeh, F., Meers, J., Moreton, J., …Tarlinton, R. E. (in press). Identification of stable reference genes for quantitative PCR in koalas. Scientific Reports, 8, Article 3364. https://doi.org/10.1038/s41598-018-21723-0

To better understand host and immune response to diseases, gene expression studies require identification of reference genes with stable expression for accurate normalisation. This study describes the identification and testing of reference genes wit... Read More about Identification of stable reference genes for quantitative PCR in koalas.

RNA expression of TLR10 in normal equine tissues (2016)
Journal Article
Tarlinton, R. E., Alder, L., Moreton, J., Maboni, G., Emes, R. D., & Tötemeyer, S. (2016). RNA expression of TLR10 in normal equine tissues. BMC Research Notes, 9, Article 353. https://doi.org/10.1186/s13104-016-2161-9

Background: Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. Results: This paper describes the genetic structure of... Read More about RNA expression of TLR10 in normal equine tissues.

Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis (2016)
Journal Article
Bonthala, V. S., Mayes, S., Moreton, J., Blythe, M. J., Wright, V., May, S., …Twycross, J. (2016). Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis. PLoS ONE, 11(2), Article e0148771. https://doi.org/10.1371/journal.pone.0148771

Bambara groundnut (Vigna subterranea (L.) Verdc.) is an African legume and is a promising underutilized crop with good seed nutritional values. Low temperature stress in a number of African countries at night, such as Botswana, can effect the growth... Read More about Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis.

Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes (2016)
Journal Article
Moreton, J., Izquierdo, A., & Emes, R. D. (2016). Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes. Frontiers in Genetics, 6, Article 361. https://doi.org/10.3389/fgene.2015.00361

De novo assembly of a complete transcriptome without the need for a guiding reference genome is attractive, particularly where the cost and complexity of generating a eukaryote genome is prohibitive. The transcriptome should not however be seen as ju... Read More about Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes.

The complete plasmid sequences of Salmonella enterica serovar Typhimurium U288 (2014)
Journal Article
Hooton, S. P., Timms, A. R., Cummings, N. J., Moreton, J., Wilson, R., & Connerton, I. F. (2014). The complete plasmid sequences of Salmonella enterica serovar Typhimurium U288. Plasmid, 76, 32-39. https://doi.org/10.1016/j.plasmid.2014.08.002

Salmonella enterica Serovar Typhimurium U288 is an emerging pathogen of pigs. The strain contains three plasmids of diverse origin that encode traits that are of concern for food security and safety, these include antibiotic resistant determinants, a... Read More about The complete plasmid sequences of Salmonella enterica serovar Typhimurium U288.

A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome (2014)
Journal Article
Moreton, J., Dunham, S. P., & Emes, R. D. (2014). A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome. Frontiers in Genetics, 5, Article 190. https://doi.org/10.3389/fgene.2014.00190

For vertebrate organisms where a reference genome is not available, de novo transcriptome assembly enables a cost effective insight into the identification of tissue specific or differentially expressed genes and variation of the coding part of the g... Read More about A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome.

Characterisation of the horse transcriptome from immunologically active tissues (2014)
Journal Article
Moreton, J., Malla, S., Aboobaker, A., Tarlinton, R. E., & Emes, R. D. (2014). Characterisation of the horse transcriptome from immunologically active tissues. PeerJ, 2, Article e382. https://doi.org/10.7717/peerj.382

The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the... Read More about Characterisation of the horse transcriptome from immunologically active tissues.

Complete genome sequence of universal bacteriophage host strain Campylobacter jejuni subsp. jejuni PT14 (2013)
Journal Article
Brathwaite, K. J., Siringan, P., Moreton, J., Wilson, R., & Connerton, I. F. (2013). Complete genome sequence of universal bacteriophage host strain Campylobacter jejuni subsp. jejuni PT14. Genome Announcements, 1(6), 1-2. https://doi.org/10.1128/genomea.00969-13

Campylobacter jejuni strain PT14 is a clinical isolate previously used to propagate bacteriophages in the United Kingdom phage typing scheme. The strain has proven useful in the isolation of Campylobacter bacteriophages from several sources, and it f... Read More about Complete genome sequence of universal bacteriophage host strain Campylobacter jejuni subsp. jejuni PT14.

Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence (2013)
Journal Article
Mahdavi, J., Royer, P., Sjolinder, H. S., Azimi, S., Self, T., Stoof, J., …Ala'Aldeen, D. A. (2013). Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence. Open Biology, 3, Article e130048. https://doi.org/10.1098/rsob.130048

Interactions between commensal pathogens and hosts are critical for disease development but the underlying mechanisms for switching between the commensal and virulent states are unknown. We show that the human pathogen Neisseria meningitidis, the lea... Read More about Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence.

Complete genome sequence of Salmonella enterica serovar Typhimurium U288 (2013)
Journal Article
Hooton, S. P., Timms, A. R., Moreton, J., Wilson, R., & Connerton, I. F. (2013). Complete genome sequence of Salmonella enterica serovar Typhimurium U288. Genome Announcements, 1(4), https://doi.org/10.1128/genomeA.00467-13

Salmonella enterica serovar Typhimurium U288 has firmly established itself within the United Kingdom pig production industry. The prevalence of this highly pathogenic multidrug-resistant serovar at such a critical point in the food chain is therefore... Read More about Complete genome sequence of Salmonella enterica serovar Typhimurium U288.

High through-put sequencing of the Parhyale hawaiensis mRNAs and microRNAs to aid comparative developmental studies (2012)
Journal Article
Blythe, M. J., Malla, S., Everall, R., Shih, Y., Lemay, V., Moreton, J., …Aboobaker, A. (2012). High through-put sequencing of the Parhyale hawaiensis mRNAs and microRNAs to aid comparative developmental studies. PLoS ONE, 7(3), Article e33784. https://doi.org/10.1371/journal.pone.0033784

Understanding the genetic and evolutionary basis of animal morphological diversity will require comparative developmental studies that use new model organisms. This necessitates development of tools for the study of genetics and also the generation o... Read More about High through-put sequencing of the Parhyale hawaiensis mRNAs and microRNAs to aid comparative developmental studies.

Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing (2012)
Journal Article
Brown, K., Moreton, J., Malla, S., Aboobaker, A. A., Emes, R. D., & Tarlinton, R. E. (2012). Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing. Virology, 433(1), https://doi.org/10.1016/j.virol.2012.07.010

The recently released draft horse genome is incompletely characterised in terms of its repetitive element pro?le. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse genome based on a data-mining strategy using mur... Read More about Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing.