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Cancer cell associated glycans as targets for immunotherapy (2015)
Journal Article
Vankemmelbeke, M., Chua, J. X., & Durrant, L. (2016). Cancer cell associated glycans as targets for immunotherapy. 00 Journal not listed, 5(1), doi:10.1080/2162402X.2015.1061177

Therapeutic anti-glycan antibodies for cancer treatment are limited, in spite of the differential glycophenotype of cancer cells and associated biology. We have generated anti-Le glycan antibodies with clinical potential and multifaceted functionalit... Read More

Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity (2015)
Journal Article
Chua, J., Vankemmelbeke, M., McIntosh, R. S., Clarke, P. A., Moss, R., Parsons, T., …Durrant, L. (2015). Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity. Clinical Cancer Research, 21(13), 2963–2974. doi:10.1158/1078-0432.CCR-14-3030

Purpose: To produce antitumor monoclonal antibodies (mAbs) targeting glycans as they are aberrantly expressed in tumors and are coaccessory molecules for key survival pathways. Experimental Design: Two mAbs (FG88.2 and FG88.7) recognizing novel tu... Read More