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All Outputs (3)

Therapeutic potential of transdermal glyceryl trinitrate in the management of acute stroke (2016)
Journal Article
Appleton, J. P., Sprigg, N., & Bath, P. M. (in press). Therapeutic potential of transdermal glyceryl trinitrate in the management of acute stroke. CNS Drugs, https://doi.org/10.1007/s40263-016-0387-7

The nitric oxide donor, glyceryl trinitrate (GTN), is a candidate treatment for the management of acute stroke with haemodynamic and potential reperfusion and neuroprotective effects. When administered as a transdermal patch during the acute and suba... Read More about Therapeutic potential of transdermal glyceryl trinitrate in the management of acute stroke.

Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor (2016)
Journal Article
Dixon, M., Appleton, J., Scutt, P., England, T., Havard, D., Howard, H., …Bath, P. (2016). Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor. Emergency Medicine Journal, 33(9), e13-e14. https://doi.org/10.1136/emermed-2016-206139.42

Rationale High blood pressure (BP) is common in acute stroke and is associated with poor outcome. Previous hospital-based trials testing the effects of BP lowering on functional outcome have been inconclusive. The PIL-FAST and RIGHT pilot trials conf... Read More about Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2(right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor.

Blood pressure management in acute stroke (2016)
Journal Article
Appleton, J. P., Sprigg, N., & Bath, P. M. (in press). Blood pressure management in acute stroke. Stroke and Vascular Neurology, 1(2), https://doi.org/10.1136/svn-2016-000020

Blood pressure (BP) is elevated in 75% or more of patients with acute stroke and is associated with poor outcomes. Whether to modulate BP in acute stroke has long been debated. With the loss of normal cerebral autoregulation, theoretical concerns are... Read More about Blood pressure management in acute stroke.