Research Repository

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The burden of childhood atopic dermatitis in the primary care setting: a report from the Meta-LARC Consortium (2018)
Journal Article
Al-Naqeeb, J., Danner, S., Fagnan, L. J., Ramsey, K., Michaels, L., Mitchell, J., …Simpson, E. L. (in press). The burden of childhood atopic dermatitis in the primary care setting: a report from the Meta-LARC Consortium. Journal of the American Board of Family Medicine,

Background: Little is known about the burden of AD encountered in U.S. primary care practices and the frequency and type of skin care practices routinely used in children. Objectives: To estimate the prevalence of AD and allergic comorbidities in... Read More

The challenges posed by equine arboviruses (2018)
Journal Article
Chapman, G. E., Baylis, M., Archer, D., & Daly, J. M. (2018). The challenges posed by equine arboviruses. Equine Veterinary Journal, 50(4), doi:10.1111/evj.12829. ISSN 0425-1644

Equine populations worldwide are at increasing risk of infection by viruses transmitted by biting arthropods including mosquitoes, biting midges (Culicoides), sandflies and ticks. These include the flaviviruses (Japanese encephalitis, West Nile and M... Read More

How is Europe positioned for a re-emergence of Schmallenberg virus? (2017)
Journal Article
Stavrou, A., Daly, J. M., Maddison, B. C., Gough, K. C., & Tarlinton, R. E. (2017). How is Europe positioned for a re-emergence of Schmallenberg virus?. Veterinary Journal, 230, doi:10.1016/j.tvjl.2017.04.009. ISSN 1532-2971

The Schmallenberg virus (SBV) caused a large scale epidemic in Europe from 2011–2013 infecting ruminants and causing fetal deformities after infection of pregnant animals. The main impacts of the virus were financial losses due to animal, meat and se... Read More

The optimisation of Pseudotyped viruses for the characterisation of immune responses to equine influenza virus (2016)
Journal Article
Scott, S. D., Kinsley, R., Temperton, N., & Daly, J. M. (2016). The optimisation of Pseudotyped viruses for the characterisation of immune responses to equine influenza virus. Pathogens, 5(4), doi:10.3390/pathogens5040068. ISSN 2076-0817

Pseudotyped viruses (PVs) produced by co-transfecting cells with plasmids expressing lentiviral core proteins and viral envelope proteins are potentially powerful tools for studying various aspects of equine influenza virus (EIV) biology. The aim of... Read More

Canine parvovirus (CPV-2) variants circulating in Nigerian dogs (2016)
Journal Article
Apaa, T., Daly, J. M., & Tarlinton, R. E. (2016). Canine parvovirus (CPV-2) variants circulating in Nigerian dogs. Veterinary Record Open, 3(1), doi:10.1136/ vetreco-2016-000198. ISSN 2052-6113

Canine parvovirus type 2 (CPV-2) is a highly contagious viral disease with three variants (CPV-2a, CPV-2b and CPV-2c) currently circulating in dogs worldwide. The main aim of this study was to determine the prevalent CPV-2 variant in faecal samples f... Read More

The influenza NS1 protein: what do we know in equine influenza virus pathogenesis? (2016)
Journal Article
Barba, M., & Daly, J. M. (2016). The influenza NS1 protein: what do we know in equine influenza virus pathogenesis?. Pathogens, 5(3), doi:10.3390/pathogens5030057. ISSN 2076-0817

Equine influenza virus remains a serious health and potential economic problem throughout most parts of the world, despite intensive vaccination programs in some horse populations. The influenza non-structural protein 1 (NS1) has multiple functions i... Read More

Small animal disease surveillance: respiratory disease (2016)
Journal Article
Sánchez-Vizcaíno, F., Daly, J. M., Jones, P. H., Dawson, S., Gaskell, R., Menacere, T., …Radford, A. D. (2016). Small animal disease surveillance: respiratory disease. Veterinary Record, 178(15), doi:10.1136/vr.i1815. ISSN 0042-4900

This second Small Animal Disease Surveillance report focuses on syndromic surveillance of i) respiratory disease in veterinary practice and ii) feline calicivirus (FCV) based on laboratory diagnosis, in a large veterinary-visiting pet population of t... Read More

Controlling equine influenza: traditional to next generation serological assays (2016)
Journal Article
Kinsley, R., Scott, S. D., & Daly, J. M. (2016). Controlling equine influenza: traditional to next generation serological assays. Veterinary Microbiology, 187, doi:10.1016/j.vetmic.2016.03.006. ISSN 0378-1135

Serological assays provide an indirect route for the recognition of infectious agents via the detection of antibodies against the infectious agent of interest within serum. Serological assays for equine influenza A virus can be applied for different... Read More

Technical considerations for the generation of novel pseudotyped viruses (2016)
Journal Article
King, B., Temperton, N., Grehan, K., Scott, S. D., Wright, E., Tarr, A. W., & Daly, J. M. (2016). Technical considerations for the generation of novel pseudotyped viruses. Future Virology, 11(1), doi:10.2217/fvl.15.106. ISSN 1746-0794

A pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studie... Read More

Modulation of potassium channels inhibits bunyavirus infection (2015)
Journal Article
Hover, S., King, B., Hall, B., Loundras, E., Taqi, H., Daly, J. M., …Mankouri, J. (2015). Modulation of potassium channels inhibits bunyavirus infection. Journal of Biological Chemistry, doi:10.1074/jbc.M115.692673. ISSN 0021-9258

Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity. Bunyaviruses are transmitted via a diver... Read More

Comparison of Schmallenberg virus antibody levels detected in milk and serum from individual cows (2015)
Journal Article
Daly, J. M., King, B., Tarlinton, R. E., Gough, K. C., Maddison, B. C., & Blowey, R. (2015). Comparison of Schmallenberg virus antibody levels detected in milk and serum from individual cows. BMC Veterinary Research, 11, doi:10.1186/s12917-015-0365-1. ISSN 1746-6148

BACKGROUND: Schmallenberg virus (SBV) is a recently emerged virus of ruminants in Europe. Enzyme-linked immunosorbent assays (ELISA) are commonly used to detect SBV-specific antibodies in bulk tank milk samples to monitor herd exposure to infection.... Read More

Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells (2015)
Journal Article
Al-Mubarak, F., Daly, J. M., Christie, D., Fountain, D., & Dunham, S. P. (2015). Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells. Virus Research, 199, doi:10.1016/j.virusres.2015.01.005. ISSN 0168-1702

Although wild ducks are considered to be the major reservoirs for most influenza A virus subtypes, they are typically resistant to the effects of the infection. In contrast, certain influenza viruses may be highly pathogenic in other avian hosts such... Read More

High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistance (2014)
Journal Article
Seng, L., Daly, J. M., Chang, K., & Kuchipudi, S. V. (2014). High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistance. PLoS ONE, 9, doi:10.1371/journal.pone.0109023. ISSN 1932-6203

Respiratory epithelial cells play a key role in influenza A virus (IAV) pathogenesis and host innate response. Transformed human respiratory cell lines are widely used in the study of IAV−host interactions due to their relative convenience, and inher... Read More

Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy (2013)
Journal Article
Daly, J. M., & Elton, D. (2013). Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy. Vaccine, 31(51), doi:10.1016/j.vaccine.2013.06.070. ISSN 0264-410X

The calculation of pepitope values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the pepitope value to equine influenza vaccine strain selection was assessed. There was a ne... Read More

The genetics of virus particle shape in equine influenza A virus (2013)
Journal Article
Elton, D., Bruce, E. A., Bryant, N., Wise, H. M., MacRae, S., Rash, A., …Digard, P. (2013). The genetics of virus particle shape in equine influenza A virus. Influenza and Other Respiratory Viruses, 7(s4), doi:10.1111/irv.12197. ISSN 1750-2640

Background Many human strains of influenza A virus produce highly pleomorphic virus particles that at the extremes can be approximated as either spheres of around 100 nm diameter or filaments of similar cross-section but elongated to lengths of many... Read More

What can mathematical models bring to the control of equine influenza? (2013)
Journal Article
Daly, J. M., Newton, J., Wood, J., & Park, A. (in press). What can mathematical models bring to the control of equine influenza?. Equine Veterinary Journal, 45(6), doi:10.1111/evj.12104. ISSN 0425-1644

Mathematical modelling of infectious disease is increasingly regarded as an important tool in the development of disease prevention and control measures. This article brings together key findings from various modelling studies conducted over the past... Read More