Research Repository

See what's under the surface


Drug-induced injury due to flucloxacillin: relevance of multiple HLA alleles (2018)
Journal Article
Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., …Daly, A. K. (in press). Drug-induced injury due to flucloxacillin: relevance of multiple HLA alleles. CPT: Pharmacometrics and Systems Pharmacology,

Some patients prescribed flucloxacillin (~0.01%) develop drug-induced liver injury (DILI). HLAB*57:01 is an established genetic risk factor for flucloxacillin DILI. To consolidate this finding, identify additional genetic factors and assess relevance... Read More

ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis (2018)
Journal Article
Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., …George, J. (in press). ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis. Hepatology, ISSN 0270-9139

Background and Aim: Given the high global prevalence of non-alcoholic fatty liver disease (NAFLD), the need for relevant non-invasive biomarkers and algorithms to accurately stage disease severity is a critical unmet medical need. Identifying those w... Read More

Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications (2018)
Journal Article
Kaliyaperumal, K., Grove, J. I., Delahay, R. M., Griffiths, W. J., Duckworth, A., & Aithal, G. P. (in press). Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications. Journal of Hepatology, doi:10.1016/j.jhep.2018.05.013. ISSN 0168-8278

A number of drug-specific and host-related factors contribute to the development of drug-induced liver injury (DILI). Investigations focused on genetic susceptibility to DILI have advanced our understanding of the pathogenesis of this rare, yet poten... Read More

Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms? (2016)
Journal Article
Grove, J. I., Austin, M., Tibble, J., Aithal, G. P., & Verma, S. (2016). Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?. Annals of Hepatology, 15(2), 277-282

Multiple genetic and environmental factors interact to determine an individual’s predisposition to non-alcoholic fatty liver disease and its phenotypic characteristics. Association studies have found a number of alleles associated with the developmen... Read More

Human leukocyte antigen genetic risk factors of drug-induced liver toxicology (2014)
Journal Article
Grove, J., & Aithal, G. (2014). Human leukocyte antigen genetic risk factors of drug-induced liver toxicology. Expert Opinion on Drug Metabolism and Toxicology, 11(3), 395-409. doi:10.1517/17425255.2015.992414

Introduction: Drug-induced liver injury (DILI) is a rare adverse drug reaction, which impacts significantly on patients. Human leukocyte antigen (HLA) risk alleles have been found to be associated with DILI supporting an immunological basis to DILI p... Read More

Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of Helicobacter pylori (2013)
Journal Article
Grove, J. I., Alandiyjany, M. N., & Delahay, R. M. (2013). Site-specific relaxase activity of a VirD2-like protein encoded within the tfs4 genomic island of Helicobacter pylori. Journal of Biological Chemistry, 288(37), doi:10.1074/jbc.M113.496430. ISSN 0021-9258

Four different type IV secretion systems are variously represented in the genomes of different Helicobacter pylori strains. Two of these, encoded by tfs3 and tfs4 gene clusters are contained within self-transmissible genomic islands. Although chromos... Read More