All Outputs (2)

Human leukocyte antigen genetic risk factors of drug-induced liver toxicology (2014)
Journal Article
Grove, J., & Aithal, G. (2014). Human leukocyte antigen genetic risk factors of drug-induced liver toxicology. Expert Opinion on Drug Metabolism and Toxicology, 11(3), 395-409. doi:10.1517/17425255.2015.992414

Introduction: Drug-induced liver injury (DILI) is a rare adverse drug reaction, which impacts significantly on patients. Human leukocyte antigen (HLA) risk alleles have been found to be associated with DILI supporting an immunological basis to DILI p... Read More about Human leukocyte antigen genetic risk factors of drug-induced liver toxicology.

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus (2014)
Journal Article
Upton, A. L., Grove, J. I., Mahdi, A. A., Briggs, G. S., Milner, D. S., Rudolph, C. J., & Lloyd, R. G. (2014). Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus. Nucleic Acids Research, 42(9), 5702-5714. https://doi.org/10.1093/nar/gku228

RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands. Its ability to remodel replication forks and to genetically interact wi... Read More about Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus.