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Palladium-catalyzed enantioselective C–H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands (2017)
Journal Article
Smalley, A. P., Cuthbertson, J. D., & Gaunt, M. J. (2017). Palladium-catalyzed enantioselective C–H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands. Journal of the American Chemical Society, 139(4), 1412-1415. doi:10.1021/jacs.6b12234

The design of an enantioselective Pd(II)-catalyzed C−H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable aziridines in high enantiomeric ra... Read More

Native functionality in triple catalytic cross-coupling: sp(3) C-H bonds as latent nucleophiles (2016)
Journal Article
Shaw, M. H., Shurtleff, V. W., Terrett, J. A., Cuthbertson, J. D., & MacMillan, D. W. (2016). Native functionality in triple catalytic cross-coupling: sp(3) C-H bonds as latent nucleophiles. Science, 352(6291), 1304-1308. doi:10.1126/science.aaf6635

The use of sp3 C–H bonds—which are ubiquitous in organic molecules—as latent nucleophile equivalents for transition metal–catalyzed cross-coupling reactions has the potential to substantially streamline synthetic efforts in organic chemistry while by... Read More

Switching on elusive organometallic mechanisms with photoredox catalysis (2015)
Journal Article
Terrett, J. A., Cuthbertson, J., Shurtleff, V. W., & MacMillan, D. W. (2015). Switching on elusive organometallic mechanisms with photoredox catalysis. Nature, 524(7565), 330-334. doi:10.1038/nature14875

Transition-metal-catalysed cross-coupling reactions have become one of the most used carbon–carbon and carbon–heteroatom bond-forming reactions in chemical synthesis. Recently, nickel catalysis has been shown to participate in a wide variety of C−C b... Read More