Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11
(2018)
Journal Article
Spiliotopoulos, A., Blokpoel Ferreras, L., Densham, R. M., Caulton, S. G., Maddison, B. C., Morris, J. R., …Dreveny, I. (in press). Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11. Journal of Biological Chemistry, doi:10.1074/jbc.ra118.004469
Ubiquitin specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined non-catalytic domains in USP4 and USP15 are known to interact with E3 ligases and substrate recruitment factors. No such interactions ha... Read More