Research Repository

See what's under the surface


Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays (2018)
Journal Article
Greenspon, C. M., Battell, E. E., Devonshire, I. M., Donaldson, L. F., Chapman, V., & Hathway, G. J. (2019). Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays. Journal of Physiology, 597(2), 377-397. doi:10.1113/jp277036

The dorsal spinal cord (DH) is a complex laminar structure integrating peripheral signals into the central nervous system. Spinal somatosensory processing is commonly measured electrophysiologically in vivo by recording the activity of individual Wid... Read More

Age dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article
H-T. Kwok, C., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., …Hathway, G. J. (2017). Age dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. PAIN, 158(11), doi:10.1097/j.pain.0000000000001027. ISSN 0304-3959

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More

Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex (2015)
Journal Article
Devonshire, I. M., Greenspon, C. M., & Hathway, G. J. (2015). Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex. Neuroscience, 305, doi:10.1016/j.neuroscience.2015.08.004

Primary somatosensory cortex (S1) contains a nociceptive map that localizes potential tissue damage on the body and encodes stimulus intensity. An objective and specific biomarker of pain however is currently lacking and is urgently required for use... Read More

A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes (2015)
Journal Article
noxious stimulation-evoked withdrawal reflexes. European Journal of Neuroscience, 42(1), doi:10.1111/ejn.12942. ISSN 0953-816X

The rostral ventromedial medulla (RVM) regulates a range of involuntary behaviours but is most often associated with nociception via the action of pronociceptive ON cells and antinociceptive OFF cells. The phasic responses of ON and OFF cells determi... Read More

Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat (2014)
Journal Article
Bennett, A., Kwok, C. H., Devonshire, I. M., & Hathway, G. J. (2014). Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat. PAIN, 155(1), 168-178. doi:10.1016/j.pain.2013.09.022

Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Her... Read More