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All Outputs (8)

Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays (2018)
Journal Article
Greenspon, C. M., Battell, E. E., Devonshire, I. M., Donaldson, L. F., Chapman, V., & Hathway, G. J. (2019). Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays. Journal of Physiology, 597(2), 377-397. https://doi.org/10.1113/jp277036

The dorsal spinal cord (DH) is a complex laminar structure integrating peripheral signals into the central nervous system. Spinal somatosensory processing is commonly measured electrophysiologically in vivo by recording the activity of individual Wid... Read More about Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article
H-T. Kwok, C., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., …Hathway, G. J. (2017). Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. PAIN, 158(11), 2222-2232. https://doi.org/10.1097/j.pain.0000000000001027

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More about Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.

Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain? (2017)
Journal Article
Devonshire, I. M., Burston, J., Xu, L., Lillywhite, A., Prior, M., Watson, D. J., …Chapman, V. (2017). Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?. NeuroImage, 157, https://doi.org/10.1016/j.neuroimage.2017.06.034

Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant sp... Read More about Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?.

Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex (2015)
Journal Article
Devonshire, I. M., Greenspon, C. M., & Hathway, G. J. (2015). Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex. Neuroscience, 305, https://doi.org/10.1016/j.neuroscience.2015.08.004

Primary somatosensory cortex (S1) contains a nociceptive map that localizes potential tissue damage on the body and encodes stimulus intensity. An objective and specific biomarker of pain however is currently lacking and is urgently required for use... Read More about Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex.

A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes (2015)
Journal Article
Devonshire, I. M., Kwok, C., Suvik, A., Haywood, A. R., Cooper, A. H., & Hathway, G. (in press). A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes. European Journal of Neuroscience, 42(1), https://doi.org/10.1111/ejn.12942

The rostral ventromedial medulla (RVM) regulates a range of involuntary behaviours but is most often associated with nociception via the action of pronociceptive ON cells and antinociceptive OFF cells. The phasic responses of ON and OFF cells determi... Read More about A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes.

Risk-based learning games improve long-term retention of information among school pupils (2014)
Journal Article
Devonshire, I. M., Davis, J., Fairweather, S., Highfield, L., Thaker, C., Walsh, A., …Hathway, G. J. (2014). Risk-based learning games improve long-term retention of information among school pupils. PLoS ONE, 9(7), Article e103640. https://doi.org/10.1371/journal.pone.0103640

Risk heightens motivation and, if used appropriately, may have the potential to improve engagement in the classroom. We have developed a risk-based learning game for school pupils in order to test whether such learning games can improve later recall... Read More about Risk-based learning games improve long-term retention of information among school pupils.

Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat (2014)
Journal Article
Bennett, A., Kwok, C. H., Devonshire, I. M., & Hathway, G. J. (2014). Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat. PAIN, 155(1), 168-178. https://doi.org/10.1016/j.pain.2013.09.022

Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Her... Read More about Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat.