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Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia (2020)
Journal Article
Lugo Leija, H. A., Velickovic, K., Bloor, I., Sacks, H., Symonds, M. E., & Sottile, V. (2020). Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia. Journal of Cellular and Molecular Medicine, 24(19), 11434-11444. https://doi.org/10.1111/jcmm.15749

Beige adipocytes possess the morphological and biochemical characteristics of brown adipocytes, including the mitochondrial uncoupling protein (UCP)1. Mesenchymal stem cells (MSCs) are somatic multipotent progenitors which differentiate into lipid-la... Read More about Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia.

Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue (2020)
Journal Article
Aldiss, P., Lewis, J. E., Lupini, I., Bloor, I., Chavoshinejad, R., Boocock, D. J., …Symonds, M. E. (2020). Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue. Frontiers in Endocrinology, 11, Article 97. https://doi.org/10.3389/fendo.2020.00097

© Copyright © 2020 Aldiss, Lewis, Lupini, Bloor, Chavoshinejad, Boocock, Miles, Ebling, Budge and Symonds. Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneu... Read More about Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue.

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo (2019)
Journal Article
Velickovic, K., Wayne, D., Lugo Leija, H. A., Bloor, I., Morris, D. E., Law, J., …Sottile, V. (2019). Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Scientific Reports, 9(1), Article 9104. https://doi.org/10.1038/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nut... Read More about Caffeine exposure induces browning features in adipose tissue in vitro and in vivo.

Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet (2019)
Journal Article
Aldiss, P., Lewis, J., Boocock, D., Miles, A., Bloor, I., Ebling, F., …Symonds, M. (2019). Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet. Nutrients, 11(5), Article 1065. https://doi.org/10.3390/nu11051065

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Brown adipose tissue (BAT) function may depend on its anatomical location and developmental origin. Interscapular BAT (iBAT) regulates acute macronutrient metabolism, whilst perivascular BAT (... Read More about Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet.

Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro (2018)
Journal Article
Velickovic, K., Lugo-Leija, H. A., Bloor, I., Law, J., Sacks, H., Symonds, M. E., & Sottile, V. (2018). Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro. Scientific Reports, 8, Article 4974. https://doi.org/10.1038/s41598-018-23267-9

Brown and beige adipocytes are characterised as expressing the unique mitochondrial uncoupling protein (UCP)1 for which the primary stimulus in vivo is cold exposure. The extent to which cold-induced UCP1 activation can also be achieved in vitro, and... Read More about Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro.

The placenta, maternal diet and adipose tissue development in the newborn (2017)
Journal Article
Symonds, M. E., Bloor, I., Ojha, S., & Budge, H. (2017). The placenta, maternal diet and adipose tissue development in the newborn. Annals of Nutrition and Metabolism, 70(3), 232-235. https://doi.org/10.1159/000464301

Background: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other orga... Read More about The placenta, maternal diet and adipose tissue development in the newborn.