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All Outputs (6)

A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial (2015)
Journal Article
Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., …Thomas, K. S. (2015). A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial. Trials, 16(1), https://doi.org/10.1186/s13063-015-0921-9

Background Eczema is a chronic, itchy skin condition that can have a large impact on the quality of life of patients and their families. People with eczema are often keen to try out non-pharmacological therapies like silk therapeutic garments that... Read More about A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial.

Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial (2015)
Journal Article
Ormerod, A. D., Thomas, K. S., Craig, F. E., Mitchell, E., Greenlaw, N., Norrie, J., …UK Dermatology Clinical Trials Network’s STOP GAP team. (2015). Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial. BMJ, 350, Article h2958. https://doi.org/10.1136/bmj.h2958

Objective: To determine whether ciclosporin is superior to prednisolone for the treatment of pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for management. Design: Multicentre, parallel group, observer blind, ran... Read More about Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.

Validation of treatment escalation as a definition of atopic eczema flares (2015)
Journal Article
Thomas, K. S., Stuart, B., O’Leary, C., Schmitt, J., Paul, C., Williams, H., & Langan, S. (2015). Validation of treatment escalation as a definition of atopic eczema flares. PLoS ONE, 10(4), 1-13. https://doi.org/10.1371/journal.pone.0124770

Background Atopic eczema (AE) is a chronic disease with flares and remissions. Long-term control of AE flares has been identified as a core outcome domain for AE trials. However, it is unclear how flares should be defined and measured. Objective... Read More about Validation of treatment escalation as a definition of atopic eczema flares.

The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology (2015)
Journal Article
Schmitt, J., Apfelbacher, C., Spuls, P. I., Thomas, K. S., Simpson, E. L., Furue, M., …Williams, H. C. (2015). The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology. Journal of Investigative Dermatology, 135(1), 24-30. https://doi.org/10.1038/jid.2014.320

Core outcome sets (COSs) are consensus-derived minimum sets of outcomes to be assessed in a specific situation. COSs are being increasingly developed to limit outcome-reporting bias, allow comparisons across trials, and strengthen clinical decision m... Read More about The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology.

What is a pragmatic clinical trial? (2015)
Journal Article
Williams, H. C., BURDEN-TEH, E., & Nunn, A. J. (2015). What is a pragmatic clinical trial?. Journal of Investigative Dermatology, 135(6), 1-3. doi:10.1038/jid.2015.134