All Outputs (33)

Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life (2019)
Journal Article
Abubara, K., Ye, M., McCulloch, C. E., Sullivan, A., Margolis, D. J., Strachan, D. P., …Langan, S. M. (2019). Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life. Journal of Allergy and Clinical Immunology, 144(3), 710–719. https://doi.org/10.1016/j.jaci.2019.05.040

Background Atopic eczema onset is described primarily in early childhood; the frequency and characteristics of adult-onset disease remain controversial. Objective To determine the proportion of individuals who report atopic eczema symptoms between... Read More about Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life.

Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Chuchu, N., Saleh, D., Bayliss, S. E., Takwoingi, Y., …Williams, H. C. (2018). Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults. Cochrane Database of Systematic Reviews, 2018(12), 1-154. https://doi.org/10.1002/14651858.CD013191

Background Early accurate detection of all skin cancer types is important to guide appropriate management and to improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damag... Read More about Reflectance confocal microscopy for diagnosising keratinocyte skin cancers in adults.

High frequency ultrasound for the diagnosis of skin cancer in adults (2018)
Journal Article
Dinnes, J., Bamber, J., Chuchu, N., Bayliss, S. E., Takwoingi, Y., Davenport, C., …Williams, H. C. (2018). High frequency ultrasound for the diagnosis of skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013188. https://doi.org/10.1002/14651858.CD013188

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about High frequency ultrasound for the diagnosis of skin cancer in adults.

Visual inspection for the diagnosis of cutaneous melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Grainge, M. J., Chuchu, N., Ferrante di Ruffano, L., Matin, R. N., …Williams, H. C. (2018). Visual inspection for the diagnosis of cutaneous melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013194. https://doi.org/10.1002/14651858.CD013194

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious... Read More about Visual inspection for the diagnosis of cutaneous melanoma in adults.

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Saleh, D., Chuchu, N., Bayliss, S. E., Patel, L., …Williams, H. C. (2018). Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013190. https://doi.org/10.1002/14651858.CD013190

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving sur... Read More about Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

Teledermatology for the diagnosis of skin cancer in adults (2018)
Journal Article
Chuchu, N., Dinnes, J., Takwoingi, Y., Matin, R. N., Bayliss, S. E., Davenport, C., …Williams, H. C. (2018). Teledermatology for the diagnosis of skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013193. https://doi.org/10.1002/14651858.CD013193

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high risk skin cancers which have the potential to metast... Read More about Teledermatology for the diagnosis of skin cancer in adults.

Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults (2018)
Journal Article
Ferrante di Ruffano, L., Dinnes, J., Chuchu, N., Bayliss, S. E., Takwoingi, Y., Davenport, C., …Williams, H. C. (2018). Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013187. https://doi.org/10.1002/14651858.CD013187

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin with potential to infiltrate and dama... Read More about Exfoliative cytology for the diagnosis of basal cell carcinoma and other skin cancers in adults.

Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma (2018)
Journal Article
Chuchu, N., Takwoingi, Y., Dinnes, J., Matin, R. N., Bassett, O., Moreau, J. F., …Williams, H. C. (2018). Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma. Cochrane Database of Systematic Reviews, Article CD013192. https://doi.org/10.1002/14651858.CD013192

Background: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for the majority of skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and po... Read More about Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma.

The development of a protocol for diagnosing hand dermatitis from photographic images (2018)
Journal Article
Parsons, V., Williams, H., English, J., Llewellyn, J., Ntani, G., & Madan, I. (2018). The development of a protocol for diagnosing hand dermatitis from photographic images. Contact Dermatitis, 79(5), 270-275. https://doi.org/10.1111/cod.13053

Background: A hand photography protocol was needed to ascertain the presence and severity of dermatitis in a trial testing the effectiveness of a behaviour change intervention to prevent hand dermatitis in nurses. Methods: We developed the protocol... Read More about The development of a protocol for diagnosing hand dermatitis from photographic images.

Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness (2018)
Journal Article
Santer, M., Ridd, M. J., Francis, N. A., Stuart, B., Rumsby, K., Chorozoglou, M., …Little, P. (2018). Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness. BMJ, 361, 1-8. https://doi.org/10.1136/bmj.k1332

Objectives: To determine the clinical and cost-effectiveness of including emollient bath additives in the management of childhood eczema. Trial design: Pragmatic randomised open-label superiority trial with two parallel groups. Setting and recrui... Read More about Emollient bath additives for the treatment of childhood eczema (BATHE): multi-centre pragmatic parallel group randomised controlled trial of clinical and cost-effectiveness.

Interventions for preventing occupational irritant hand dermatitis (Review) (2018)
Journal Article
Bauer, A., Rönsch, H., Elsner, P., Dittmar, D., Bennett, C., Schuttelaar, M. A., …Williams, H. C. (in press). Interventions for preventing occupational irritant hand dermatitis (Review). Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD004414.pub3

Background: Occupational irritant hand dermatitis (OIHD) causes significant functional impairment, disruption of work, and discomfort in the working population. Different preventive measures such as protective gloves, barrier creams and moisturisers... Read More about Interventions for preventing occupational irritant hand dermatitis (Review).

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2018)
Journal Article
Chalmers, J., Thomas, K., Apfelbacher, C., Williams, H., Prinsen, C., Spuls, P., …Zaniboni, M. (2018). Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178(5), e332-e341. https://doi.org/10.1111/bjd.16543

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus... Read More about Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial (2017)
Journal Article
Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M., …Williams, H. C. (2017). Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial. Trials, 18(1), Article 343. https://doi.org/10.1186/s13063-017-2031-3

Background: Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for... Read More about Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial.

Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial (2017)
Journal Article
Mason, J., Thomas, K., Ormerod, A., Craig, F., Mitchell, E., Norrie, J., & Williams, H. (2017). Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial. British Journal of Dermatology, 177(6), 1527-1536. https://doi.org/10.1111/bjd.15561

Background Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial... Read More about Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial.

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial (2017)
Journal Article
Williams, H. C., Wojnarowska, F., Kirtschig, G., Mason, J., Godec, T. R., Schmidt, E., …Nunn, A. J. (in press). Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial. Lancet, 389(10079), https://doi.org/10.1016/S0140-6736%2817%2930560-3

Background: Bullous pemphigoid (BP) is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline conveys acceptable short-term blister control whilst conferring long-term safety advantage... Read More about Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial.

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease (2016)
Journal Article
Thomas, K. S., Batchelor, J. M., Bath-Hextall, F., Chalmers, J., Clarke, T., Crowe, S., …Williams, H. C. (2016). A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease. Programme Grants for Applied Research, 4(18), https://doi.org/10.3310/pgfar04180

Background Skin diseases are very common and can have a large impact on the quality of life of patients and caregivers. This programme addressed four diseases: (1) eczema, (2) vitiligo, (3) squamous cell skin cancer (SCC) and (4) pyoderma gangreno... Read More about A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.

Surgery Versus 5% Imiquimod for Nodularand Superficial Basal Cell Carcinoma: 5-Year Results of the SINSRandomized Controlled Trial (2016)
Journal Article
Williams, H. C., Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., …Surgery versus Imiquimod forNodular and Superficial basal cell carcinoma (SINS) study group. (2017). Surgery Versus 5% Imiquimod for Nodularand Superficial Basal Cell Carcinoma: 5-Year Results of the SINSRandomized Controlled Trial. Journal of Investigative Dermatology, 137(3), 614-619. https://doi.org/10.1016/j.jid.2016.10.019

© 2016 The Authors We previously reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial or nodular basal cell carcinoma at low-risk sites in our noninferiority randomized controlled SINS trial. Here we rep... Read More about Surgery Versus 5% Imiquimod for Nodularand Superficial Basal Cell Carcinoma: 5-Year Results of the SINSRandomized Controlled Trial.

Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews (2016)
Journal Article
Le Cleach, L., Doney, E., Katz, K. A., Williams, H. C., & Trinquart, L. (2016). Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews. Journal of Investigative Dermatology, 136(12), e125-e129. https://doi.org/10.1016/j.jid.2016.09.019

Clinical trials and basic science studies without statistically significant results are less likely to be published than studies with statistically significant results. Systematic reviews and meta-analyses that omit unpublished data are at high risk... Read More about Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews.

Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement (2016)
Journal Article
Spuls, P., Gerbens, L., Simpson, E., Apfelbacher, C., Chalmers, J., Thomas, K., …Schmitt, J. (2017). Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement. British Journal of Dermatology, 176(4), 979-984. https://doi.org/10.1111/bjd.15179

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, q... Read More about Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement.

Shared decision-making and patient decision aids in dermatology (2016)
Journal Article
Tan, J., Linos, E., Sendelweck, M. A., van Zuuren, E. J., Ersser, S., Dellavalle, R. P., & Williams, H. C. (in press). Shared decision-making and patient decision aids in dermatology. British Journal of Dermatology, 175(5), https://doi.org/10.1111/bjd.14803

Shared decision making combines individual patient interests and values with clinical best evidence under the guiding principle of patient autonomy. Patient decision aids can support shared decision making and facilitate decisions that have multiple... Read More about Shared decision-making and patient decision aids in dermatology.