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Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system (2020)
Journal Article
Mistry, H. D., Ogalde, M. V. H., Pipkin, F. B., Escher, G., & Kurlak, L. O. (2020). Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system. Frontiers in Medicine, 7, https://doi.org/10.3389/fmed.2020.00270

Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that... Read More about Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system.

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia (2020)
Journal Article
Stratikos, E., Warthan, M., Strauss, J. F., Kurlak, L. O., Seamon, K., Lee, E. D., & Mistry, H. D. (2020). The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia. Frontiers in Immunology, 11, Article 396. https://doi.org/10.3389/fimmu.2020.00396

Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta. They are involved in processes regulating blood pressure, angioge... Read More about The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.

A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy (2020)
Journal Article
Dahabiyeh, L. A., Tooth, D., Kurlak, L. O., Mistry, H. D., Pipkin, F. B., & Barrett, D. A. (2020). A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-58930-7

© 2020, The Author(s). The oxidation status of angiotensinogen (AGT) may have a critical role in pre-eclampsia. We used a validated, quantitative, mass spectrometry-based method to measure the oxidized and total AGT levels in plasma of pre-eclamptic... Read More about A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy.

Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications (2019)
Journal Article
Mistry, H. D., Kurlak, L. O., Gardner, D. S., Torffvit, O., Hansen, A., Broughton Pipkin, F., & Strevens, H. (2019). Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications. Journal of the American Heart Association, 8(13), 1-11. https://doi.org/10.1161/JAHA.119.012611

Background-—AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angiotensin... Read More about Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications.

Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD (2019)
Journal Article
Wiles, K., Bramham, K., Seed, P. T., Kurlak, L. O., Mistry, H. D., Nelson-Piercy, C., …Chappell, L. C. (2019). Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD. Kidney International Reports, 4(6), 842-853. https://doi.org/10.1016/j.ekir.2019.03.012

© 2019 International Society of Nephrology Introduction: Diagnosis of superimposed preeclampsia in women with chronic kidney disease (CKD)is complicated by the presence of hypertension and proteinuria due to renal disease. The aims of this study were... Read More about Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD.

Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia (2019)
Journal Article
Kurlak, L. O., Broughton Pipkin, F., Mohaupt, M. G., & Mistry, H. D. (2019). Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia. Clinical Kidney Journal, 12(6), 847-854. https://doi.org/10.1093/ckj/sfz025

Background: Women with chronic kidney disease (CKD) are at increased risk of superimposed preeclampsia (SPE). Accurate identification of SPE is challenging. We hypothesised that specific components of the renin-angiotensin-aldosterone-system (RAAS) w... Read More about Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia.

Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia (2018)
Journal Article
Hentchke, M. R., da Cunha Filho, E. V., Vieira, M. C., Paula, L. G., Mistry, H. D., Pinheiro da Costa, B. E., & Poli-de-Figueiredo, C. E. (2018). Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia, 40(10), 593-598. https://doi.org/10.1055/s-0038-1670713

Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE). Methods: Case-control study c... Read More about Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia.

Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy (2018)
Journal Article
Eisele, N., Klossner, R., Escher, G., Rudloff, S., Larionov, A., Theillg, F., …Gennari-Moser, C. (2018). Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy. Journal of the American Heart Association, 7(15), Article e008363. https://doi.org/10.1161/jaha.117.008363

Background In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (BP). Reducing BP by increasing Na+ intake via plasma volume expansion appears... Read More about Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy.

Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia (2017)
Journal Article
Mistry, H. D., Kurlak, L., Mansour, Y., Zurkinden, L., Mohaupt, M., & Escher, G. (2017). Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia. Journal of Lipid Research, 58, https://doi.org/10.1194/jlr.M071985

Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD. We hypothesized that in preeclampsia there would be a disruption of maternal/fetal p... Read More about Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia.

Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice (2016)
Journal Article
Zurkinden, L., Mansour, Y., Rohrbach, B., Vogt, B., Mistry, H. D., & Escher, G. (2016). Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice. FEBS Open Bio, 6(10), https://doi.org/10.1002/2211-5463.12123

Sterol 27-hydroxylase (CYP27A1) is involved in bile acid synthesis and cholesterol homoeostasis. Cyp27a1(?/?)/Apolipoprotein E(?/?) double knockout mice (DKO) fed a western diet failed to develop atherosclerosis. Caveolin-1 (CAV-1), the main componen... Read More about Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice.

42 Negative correlation between PlGF and Endocan-1 in women with preeclampsia (2016)
Journal Article
Ribeiro Hentschke, M., Mistry, H. D., Pinheiro da Costa, B. E., & Poli-de-Figueiredo, C. E. (2016). 42 Negative correlation between PlGF and Endocan-1 in women with preeclampsia. Pregnancy Hypertension, 6(3), (157). doi:10.1016/j.preghy.2016.08.043. ISSN 2210-7789

Introduction: Endocan-1 is a soluble proteoglican specifically expressed in endothelial cells, a biomarker/predictor of vascular endothelial related pathologies, as pre-eclampsia (PE). PlGF is an angiogenic factor, and a marker of placental dysfuncti... Read More about 42 Negative correlation between PlGF and Endocan-1 in women with preeclampsia.

Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult (2016)
Journal Article
Kurlak, L., Mistry, H. D., Cindrova-Davies, T., Burton, G., & Broughton Pipkin, F. (2016). Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult. Journal of Physiology, 594(5), 1327-1340. https://doi.org/10.1113/JP271045

A functioning placental renin–angiotensin system (RAS) appears necessary for uncomplicated pregnancy and is present during placentation, which occurs under low oxygen tensions. Placental RAS is increased in pre-eclampsia (PE), characterised by placen... Read More about Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult.

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation (2016)
Journal Article
Eisele, N., Albrecht, C., Mistry, H. D., Dick, B., Baumann, M., Surbeck, D., …Gennari-Moser, C. (2016). Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation. Placenta, 40, https://doi.org/10.1016/j.placenta.2016.02.004

Aldosterone is an important factor supporting placental growth and fetal development. Recently, expression of placental growth factor (PlGF) has been observed in response to aldosterone exposure in different models of atherosclerosis. Thus, we hypoth... Read More about Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation.

Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year (2015)
Journal Article
Broughton Pipkin, F., Mistry, H. D., Roy, C., Dick, B., Waugh, J., Chikhi, R., …Mohaupt, M. (2015). Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year. Endocrine Connections, 4(4), https://doi.org/10.1530/EC-15-0084

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised... Read More about Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year.

Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum (2015)
Journal Article
Mistry, H. D., Eisele, N., Escher, G., Dick, B., Surbeck, D., Delles, C., …Gennari-Moser, C. (2015). Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum. Reproductive Biology and Endocrinology, 13, Article 101

Background: Normal pregnancy depends on pronounced adaptations in steroid hormone concentrations. Although in recent years, the understanding of these hormones in pregnancy has improved, the interpretation is hampered by insufficient reference values... Read More about Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum.

Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia (2015)
Journal Article
Smith-Jackson, K., Hentschke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Broughton Pipkin, F., Czajka, A., & Mistry, H. D. (2015). Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.001

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation o... Read More about Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia.

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system (2015)
Journal Article
Kurlak, L., Williams, P. J., Bulmer, J. N., Broughton Pipkin, F., & Mistry, H. D. (2015). Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.011

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiog... Read More about Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article
Mistry, H. D., Gill, C., Kurlak, L., Seed, P. T., Hestketh, J., Meplan, C., …Poston, L. (2015). Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia. Free Radical Biology and Medicine, 78, https://doi.org/10.1016/j.freeradbiomed.2014.10.580

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia? (2014)
Journal Article
Hentchke, M., Caruso, F. B., Paula, L. G., Medeiro, A. K., Gadonski, G., Antonello, I. C., …Pinheiro da Costa, B. (2014). Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia?. Pregnancy Hypertension, 4(2), https://doi.org/10.1016/j.preghy.2014.03.003

Objectives: The purpose of the present study was to evaluate the association between pre-eclampsia and blood groups in a group of pregnant women hospitalized in a University Hospital in Porto Alegre, Brazil -Hospital São Lucas (HSL)/PUCRS. Study de... Read More about Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia?.

Expression of voltage-dependent potassium channels in first trimester human placentae (2014)
Journal Article
Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCN... Read More about Expression of voltage-dependent potassium channels in first trimester human placentae.