Research Repository

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Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article
Stubbendorff, C., Hale, E., Cassaday, H. J., Bast, T., & Stevenson, C. W. (2019). Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology, doi:10.1007/s00213-018-5162-7

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More

The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts (2018)
Book Chapter
Cassaday, H., & Nelson, A. J. (2018). The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts. In A. Ennaceur, & M. A. de Souza Silva (Eds.), Handbook of Object Novelty Recognition, 359-369. Elsevier. doi:10.1016/b978-0-12-812012-5.00024-0

Recognition of objects and their contexts is demonstrated based on the intrinsic features of objects (‘what’), as well as for spatial (‘where’) or temporal presentation (‘when’) cues. A network of structures identified in lesion studies forms a neura... Read More

Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure (2018)
Journal Article
Pezze, M., Marshall, H., & Cassaday, H. (2018). Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure. Brain and Behavior, doi:10.1002/brb3.1147

Trace conditioning is impaired by lesions to dorsal hippocampus, as well as by treatment with the muscarinic acetylcholine antagonist scopolamine. However, the role of muscarinic receptors within hippocampus has received little attention. The present... Read More

Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay (2017)
Journal Article
Pezze, M. A., Marshall, H. J., Fone, K. C., & Cassaday, H. J. (2017). Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learning and Memory, 24, doi:10.1101/lm.044784.116. ISSN 1072-0502

Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesi... Read More

Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex (2017)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2017). Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex. Journal of Neuroscience, 37(26), doi:10.1523/JNEUROSCI.3308-16.2017. ISSN 1529-2401

The muscarinic acetylcholine (ACh) receptor is an important modulator of medial prefrontal cortex (mPFC) functions, such as the working memory required to bridge a trace interval in associative leaning. Aversive and appetitive trace conditioning proc... Read More

Overshadowing depends on cue and reinforcement sensitivity but not schizotypy (2016)
Journal Article
Pickett, C., Cassaday, H. J., & Bibby, P. A. (2017). Overshadowing depends on cue and reinforcement sensitivity but not schizotypy. Behavioural Brain Research, 321, doi:10.1016/j.bbr.2016.12.031. ISSN 0166-4328

There is evidence for impaired selective learning mechanisms in individuals high in schizotypy. Overshadowing provides a direct test of selective learning based on cue salience and has previously been reported to be impaired in relation to schizotypy... Read More

Potentiation rather than distraction in a trace fear conditioning procedure (2016)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2016). Potentiation rather than distraction in a trace fear conditioning procedure. Behavioural Processes, 128, 41-61. doi:10.1016/j.beproc.2016.04.003

Trace conditioning procedures are defined by the introduction of a trace interval between conditioned stimulus (CS, e.g. noise or light) offset and unconditioned stimulus (US, e.g. footshock). The introduction of an additional stimulus as a distracto... Read More

Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes (2015)
Journal Article
Thurston, M. D., & Cassaday, H. J. (2015). Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes. Learning and Motivation, 52, doi:10.1016/j.lmot.2015.10.002. ISSN 0023-9690

Conditioned inhibition occurs when a stimulus inhibits the responses that would normally occur to a conditioned stimulus that previously predicted an outcome of interest (the unconditioned stimulus, which elicits responding unconditionally). The pres... Read More

Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure (2015)
Journal Article
Pezze, M. A., Marshall, H., Domonkos, A., & Cassaday, H. J. (2015). Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65, doi:10.1016/j.pnpbp.2015.08.015. ISSN 0278-5846

The anterior cingulate cortex (AC) component of the medial prefrontal cortex (mPFC) has been implicated in attention and working memory as measured by trace conditioning. Since dopamine (DA) is a key modulator of mPFC function, the present study eval... Read More

Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues (2015)
Journal Article
Cassaday, H. J., & Thur, K. E. (2015). Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues. Pharmacology Biochemistry and Behavior, 129, doi:10.1016/j.pbb.2014.12.004. ISSN 0091-3057

Treatment with selective serotonin reuptake inhibitors (SSRIs) can reduce contextual conditioning. Since contexts present a variety of potentially competing cues, impaired overshadowing may provide an account of such effects. The present study theref... Read More

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations (2014)
Journal Article
Cassaday, H. J., Nelson, A. J., & Pezze, M. A. (2014). From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations. Frontiers in Neuroscience, 8(160), doi:10.3389/fnsys.2014.00160. ISSN 1662-4548

Distinctions along the dorsal-ventral axis of medial prefrontal cortex (mPFC), between anterior cingulate (AC), prelimbic (PL) and infralimbic (IL) sub-regions, have been proposed on a variety of neuroanatomical and neurophysiological grounds. Conven... Read More

Do personality traits predict individual differences in excitatory and inhibitory learning? (2013)
Journal Article
He, Z., Cassaday, H. J., Bonardi, C., & Bibby, P. A. (2013). Do personality traits predict individual differences in excitatory and inhibitory learning?. Frontiers in Psychology, 4(245), doi:10.3389/fpsyg.2013.00245. ISSN 1664-1078

Conditioned inhibition (CI) is demonstrated in classical conditioning when a stimulus is used to signal the omission of an otherwise expected outcome. This basic learning ability is involved in a wide range of normal behavior – and thus its disruptio... Read More