All Outputs (5)

A new framework for characterization of poroelastic materials using indentation (2019)
Journal Article
Esteki, M. H., Alemrajabi, A. A., Hall, C., Sheridan, G. K., Azadi, M., & Moeendarbary, E. (2020). A new framework for characterization of poroelastic materials using indentation. Acta Biomaterialia, 102, 138-148. https://doi.org/10.1016/j.actbio.2019.11.010

To characterize a poroelastic material, typically an indenter is pressed onto the surface of the material with a ramp of a finite approach velocity followed by a hold where the indenter displacement is kept constant. This leads to deformation of the... Read More about A new framework for characterization of poroelastic materials using indentation.

Inhibition of Piezo1 attenuates demyelination in the central nervous system (2019)
Journal Article
Velasco‐Estevez, M., Gadalla, K. K. E., Liñan‐Barba, N., Cobb, S., Dev, K. K., & Sheridan, G. K. (2020). Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia, 68(2), 356-375. https://doi.org/10.1002/glia.23722

Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically... Read More about Inhibition of Piezo1 attenuates demyelination in the central nervous system.

Piezo1 regulates calcium oscillations and cytokine release from astrocytes (2019)
Journal Article
Sheridan, G. K., Velasco‐Estevez, M., Dev, K. K., Rolle, S. O., & Mampay, M. (2020). Piezo1 regulates calcium oscillations and cytokine release from astrocytes. Glia, 68(1), 145-160. https://doi.org/10.1002/glia.23709

Astrocytes are important for information processing in the brain and they achieve this by fine‐tuning neuronal communication via continuous uptake and release of biochemical modulators of neurotransmission and synaptic plasticity. Often overlooked ar... Read More about Piezo1 regulates calcium oscillations and cytokine release from astrocytes.

Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy (2019)
Journal Article
Colin-York, H., Javanmardi, Y., Barbieri, L., Li, D., Korobchevskaya, K., Guo, Y., …Fritzsche, M. (2019). Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy. Nano Letters, 19(7), 4427-4434. https://doi.org/10.1021/acs.nanolett.9b01196

Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measurements are essential to understanding the role of biomechanics in cell regulation and function. Traction force microscopy remains the most broadly app... Read More about Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy.

REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain (2019)
Journal Article
Mampay, M., & Sheridan, G. K. (2019). REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain. Frontiers in Neuroendocrinology, 53, Article 100744. https://doi.org/10.1016/j.yfrne.2019.04.001

The transcriptional repressor REST (Repressor Element-1 Silencing Transcription factor)is a key modulator of the neuronal epigenome and targets genes involved in neuronal differentiation, axonal growth, vesicular transport, ion channel conductance an... Read More about REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain.