Research Repository

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Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth (2018)
Journal Article
Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), doi:10.1371/journal.pone.0201481. ISSN 1932-6203

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), wo... Read More

FGF21 is an insulin-dependent postprandial hormone in adult humans (2017)
Journal Article
Samms, R. J., Lewis, J. E., Norton, L., Stephens, F. B., Gaffney, C. J., Butterfield, T., …Tsintzas, K. (in press). FGF21 is an insulin-dependent postprandial hormone in adult humans. Journal of Clinical Endocrinology and Metabolism, doi:10.1210/jc.2017-01257. ISSN 0021-972X

Context: Fibroblast growth factor 21 (FGF21) secretion has been shown to respond directly to carbohydrate consumption, with glucose, fructose and sucrose all reported to increase plasma levels of FGF21 in rodents and humans. However, carbohydrate con... Read More

Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice (2017)
Journal Article
Oyegbami, O., Collins, H. M., Pardon, M., Ebling, F. J., Heery, D. M., & Moran, P. M. (2017). Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice. Current Alzheimer Research, 14(8), doi:10.2174/1567205014666170317113159. ISSN 1567-2050

In addition to cognitive decline, Alzheimer’s disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as ‘sundowning’. These symptoms a... Read More

Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster (2017)
Journal Article
Lewis, J. E., Samms, R. J., Cooper, S., Luckett, J. C., Perkins, A. C., Adams, A. C., …Ebling, F. J. (in press). Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. Scientific Reports, 7(1), doi:10.1038/s41598-017-03607-x. ISSN 2045-2322

FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The... Read More

Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (2017)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Cocco, C., Noli, B., Ferri, G., …Jethwa, P. (2017). Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain. PLoS ONE, 12, doi:10.1371/journal.pone.0172724. ISSN 1932-6203

VGF (non-acronymic) was first highlighted to have a role in energy homeostasis through experiments involving dietary manipulation in mice. Fasting increased VGF mRNA in the Arc and levels were subsequently reduced upon refeeding. This anabolic role f... Read More

Photoperiod-induced increases in bone mineral apposition rate in Siberian hamsters and the involvement of seasonal leptin changes (2017)
Journal Article
Kokolski, M., Ebling, F. J., Henstock, J. R., & Anderson, S. I. (2017). Photoperiod-induced increases in bone mineral apposition rate in Siberian hamsters and the involvement of seasonal leptin changes. Frontiers in Endocrinology, 8, doi:10.3389/fendo.2017.00357. ISSN 1664-2392

The adipokine leptin regulates energy balance, appetite, and reproductive maturation. Leptin also acts on bone growth and remodeling, but both osteogenic and anti-osteogenic effects have been reported depending on experimental conditions. Siberian ha... Read More

Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters (2015)
Journal Article
Samms, R. J., Lewis, J. E., Lory, A., Fowler, M. J., Cooper, S., Warner, A., …Ebling, F. J. (2015). Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters. Current Biology, 25(22), doi:10.1016/j.cub.2015.10.010. ISSN 0960-9822

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) th... Read More

Dual effects of fibroblast growth factor 21 on hepatic energy metabolism (2015)
Journal Article
Samms, R. J., Murphy, M., Fowler, M. J., Cooper, S., Emmerson, P., Coskun, T., …Tsintzas, K. (2015). Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. Journal of Endocrinology, 227(1), doi:10.1530/JOE-15-0334. ISSN 0022-0795

The aim of this study was to investigate the mechanisms by which FGF21 affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters maintained in t... Read More

Dual signal transduction pathways activated by TSH receptors in rat primary tanycyte cultures (2015)
Journal Article
Bolborea, M., Helfer, G., Ebling, F. J., & Barrett, P. (2015). Dual signal transduction pathways activated by TSH receptors in rat primary tanycyte cultures. Journal of Molecular Endocrinology, 54, doi:10.1530/JME-14-0298. ISSN 0952-5041

Tanycytes play multiple roles in hypothalamic functions, including sensing peripheral nutrients and metabolic hormones, regulating neurosecretion and mediating seasonal cycles of reproduction and metabolic physiology. This last function reflects the... Read More

Photoperiodic regulation of FGF21 production in the Siberian hamster (2014)
Journal Article
Samms, R. J., Fowler, M. J., Cooper, S., Emmerson, P., Coskun, T., Adams, A. C., …Ebling, F. J. (2014). Photoperiodic regulation of FGF21 production in the Siberian hamster. Hormones and Behavior, 66(1), doi:10.1016/j.yhbeh.2014.03.013. ISSN 0018-506X

FGF21 is an endocrine member of the fibroblast growth factor superfamily that has been shown to play an important role in the physiological response to nutrient deprivation. Food restriction enhances hepatic FGF21 production, which serves to engage a... Read More