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Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety (2015)
Journal Article
Pan-Vazquez, A., Rye, N., Ameri, M., McSparron, B., Smallwood, G., Bickerdyke, J., …Toledo-Rodriguez, M. (2015). Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety. Molecular Brain, 8(1), doi:10.1186/s13041-015-0128-8. ISSN 1756-6606

Background: Lack of physical activity and increased levels of stress contribute to the development of multiple physical and mental disorders. An increasing number of studies relate voluntary exercise with greater resilience to psychological stress, a... Read More

Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system (2015)
Journal Article
Beaven, R., Dzhindzhev, N. S., Qu, Y., Hahn, I., Dajas-Bailador, F., Ohkura, H., & Prokop, A. (2015). Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system. Molecular Biology of the Cell, 26(8), doi:10.1091/mbc.E14-06-1083. ISSN 1939-4586

Axons act like cables, electrically wiring the nervous system. Polar bundles of microtubules (MTs) form their backbones and drive their growth. Plus end–tracking proteins (+TIPs) regulate MT growth dynamics and directionality at their plus ends. Howe... Read More

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis (2014)
Journal Article
Treude, F., Kappes, F., Fahrenkamp, D., Müller-Newen, G., Dajas-Bailador, F., Krämer, O. H., …Hartkamp, J. (2014). Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. Oncotarget, 5(10), doi:10.18632/oncotarget.1634. ISSN 1949-2553

The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset of human cancers and its down-regulation serves as a mechanism for cancer cell survival following chemotherapy. PAR-4 re-expression selectively causes apoptosi... Read More