Research Repository

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sTREM-1 is elevated in cystic fibrosis and correlates with proteases (2017)
Journal Article
Forrester, D., Barr, H. L., Fogarty, A. W., & Knox, A. (in press). sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52(4), doi:10.1002/ppul.23650. ISSN 8755-6863

Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases... Read More

The differential effects of azithromycin on the airway epithelium in vitro and in vivo (2016)
Journal Article
Slater, M., Torr, E., Harrison, T. W., Forrester, D. L., Knox, A., Shaw, D. E., & Sayers, I. (2016). The differential effects of azithromycin on the airway epithelium in vitro and in vivo. Physiological Reports, 4(18), doi:10.14814/phy2.12960. ISSN 2051-817X

Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these benefi- cial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on... Read More

Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial (2015)
Journal Article
Forrester, D. L., Knox, A. J., Smyth, A. R., Barr, H. L., Simms, R., Pacey, S. J., …Fogarty, A. W. (in press). Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial. Pediatric Pulmonology, 51(3), doi:10.1002/ppul.23370. ISSN 8755-6863

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that ora... Read More

Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis (2015)
Journal Article
Barr, H. L., Halliday, N., Cámara, M., Barrett, D. A., Williams, P., Forrester, D. L., …Fogarty, A. W. (2015). Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis. European Respiratory Journal, 46(4), doi:10.1183/09031936.00225214. ISSN 0903-1936

ABSTRACT Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection. A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary e... Read More

Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study (2012)
Journal Article
Forrester, D. L., Knox, A. J., Smyth, A. R., & Fogarty, A. W. (2013). Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study. Journal of Cystic Fibrosis, 12(3), doi:10.1016/j.jcf.2012.08.008. ISSN 1569-1993

Background Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung funct... Read More