All Outputs (9)

Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI (2020)
Journal Article
Iwabuchi, S. J., Xing, Y., Cottam, W. J., Drabek, M. M., Tadjibaev, A., Fernandes, G. S., …Auer, D. P. (2020). Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI. PAIN, 161(6), 1255-1263. https://doi.org/10.1097/j.pain.0000000000001829

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity, for example, in postoperative pain after knee replacement. Other factors such as low mood,... Read More about Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain? (2017)
Journal Article
Devonshire, I. M., Burston, J., Xu, L., Lillywhite, A., Prior, M., Watson, D. J., …Chapman, V. (2017). Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?. NeuroImage, 157, https://doi.org/10.1016/j.neuroimage.2017.06.034

Application of functional imaging techniques to animal models is vital to understand pain mechanisms, but is often confounded by the need to limit movement artefacts with anaesthesia, and a focus on evoked responses rather than clinically relevant sp... Read More about Manganese-enhanced magnetic resonance imaging depicts brain activity in models of acute and chronic pain: a new window to study experimental spontaneous pain?.

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER (2017)
Journal Article
Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., …Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric... Read More about Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER.

In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies (2016)
Journal Article
Schwarz, S. T., Xing, Y., Tomar, P., Bajaj, N., & Auer, D. P. (2017). In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies. Radiology, 283(3), 789-798. https://doi.org/10.1148/radiol.2016160662

Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson disease (PD); the specific aims were (a) to study regional magnetic... Read More about In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies.

Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain (2016)
Journal Article
Abaei, M., Sagar, D. R., Stockley, E. G., Spicer, C. H., Prior, M., Chapman, V., & Auer, D. P. (in press). Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. Molecular Pain, 12, https://doi.org/10.1177/1744806916642445

Background: The mechanisms driving osteoarthritic pain remain poorly understood, but there is increasing evidence for a role of the central nervous system in the chronification of pain.We used functional magnetic resonance imaging to investigate the... Read More about Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.

The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T (2014)
Journal Article
Schwarz, S., Afzal, M., Morgan, P., Auer, D., Bajaj, N., & Gowland, P. A. (2014). The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T. PLoS ONE, 9(4), Article e93814. https://doi.org/10.1371/journal.pone.0093814

There is no well-established in vivo marker of nigral degeneration in Parkinson's disease (PD). An ideal imaging marker would directly mirror the loss of substantia nigra dopaminergic neurones, which is most prominent in sub-regions called nigrosomes... Read More about The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T.

Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors (2013)
Journal Article
Rodriguez Gutierrez, D., Awwad, A., Meijer, L., Manita, M., Jaspan, T., Dineen, R. A., …Auer, D. P. (in press). Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. American Journal of Neuroradiology, 35(5), https://doi.org/10.3174/ajnr.A3784

BACKGROUND AND PURPOSE: Qualitative radiologic MR imaging review affords limited differentiation among types of pediatric posterior fossa brain tumors and cannot detect histologic or molecular subtypes, which could help to stratify treatment. This st... Read More about Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors.

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics (2013)
Journal Article
Rodriguez Gutierrez, D., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics. Neuro-Oncology, 15(8), https://doi.org/10.1093/neuonc/not034

Background Assessment of treatment response by measuring tumor size is known to be a late and potentially confounded response index. Serial diffusion MRI has shown potential for allowing earlier and possibly more reliable response assessment in a... Read More about Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics.