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Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation (2018)
Journal Article
Roques, M., Stanway, R. R., Rea, E. I., Markus, R., Brady, D., Holder, A. A., …Tewari, R. (2018). Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation. Biology Open, doi:10.1242/bio.036822

Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also ma... Read More

Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes (2015)
Journal Article
Roques, M., Wall, R. J., Douglass, A. P., Ramaprasad, A., Ferguson, D. J. P., Kaindama, M. L., …Tewari, R. (2015). Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes. PLoS Pathogens, 11(11), doi:10.1371/journal.ppat.1005273

Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisi... Read More

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article
(PPKL) in plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathogens, 8(9), doi:10.1371/journal.ppat.1002948. ISSN 1553-7366

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development (2012)
Journal Article
Guttery, D. S., Ferguson, D. J. P., Poulin, B., Xu, Z., Straschil, U., Klop, O., …Tewari, R. (2012). A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathogens, 8(2), doi:10.1371/journal.ppat.1002554. ISSN 1553-7366

Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC... Read More

Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains (2012)
Journal Article
Bodhicharla, R., Nagarajan, A., Winter, J., Adenle, A., Nazir, A., Brady, D., …de Pomerai, D. I. (2012). Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains. CNS and Neurological Disorders - Drug Targets, 11(8), doi:10.2174/1871527311211080005. ISSN 1871-5273

The neural protein α-synuclein aggregates both in vivo and in vitro to form insoluble fibrils that are involved in Parkinson’s disease pathogenesis. We have generated α-synuclein/fluorescent-protein fusion constructs overexpressed in muscle cells of... Read More