Skip to main content

Research Repository

See what's under the surface


The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds (2019)
Journal Article
Dewey, R. S., Francis, S. T., Guest, H., Prendergast, G., Millman, R. E., Plack, C. J., & Hall, D. A. (2020). The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. NeuroImage, 204, https://doi.org/10.1016/j.neuroimage.2019.116239

© 2019 In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several... Read More about The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds.

Content validity and readability of patient-reported questionnaire instruments of hearing disability (2019)
Journal Article
Manchaiah, V., Granberg, S., Grover, V., Saunders, G., & Hall, D. (2019). Content validity and readability of patient-reported questionnaire instruments of hearing disability. International Journal of Audiology, 58(9), 565-575. doi:10.1080/14992027.2019.1602738

Objective: The current study evaluates the content validity (i.e., domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognized procedures and tools. Design: A review of the literature to... Read More about Content validity and readability of patient-reported questionnaire instruments of hearing disability.

A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial (2019)
Journal Article
Hall, D., Ray, J., Watson, J., Sharman, A., Hutchison, J., Harris, P., …Large, C. H. (2019). A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial. Hearing Research, 377, 153-166. https://doi.org/10.1016/j.heares.2019.03.018

AUT00063 is an experimental new medicine that has been demonstrated to suppress spontaneous hyperactivity by modulating the action of voltage-gated potassium-channels in central auditory cortical neurons of a rodent model. This neurobiological proper... Read More about A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial.

Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ) (2019)
Journal Article
Genitsaridi, E., Partyka, M., Gallus, S., Lopez-Escamez, J. A., Schecklmann, M., Mielczarek, M., …Hall, D. A. (2019). Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ). Hearing Research, 377, 353-359. https://doi.org/10.1016/j.heares.2019.02.017

Background The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced... Read More about Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages (2019)
Journal Article
Biswas, R., Lugo, A., Gallus, S., Akeroyd, M. A., & Hall, D. A. (2019). Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages. Hearing Research, 377, 330-338. doi:10.1016/j.heares.2019.02.008

INTRODUCTION: Prevalence estimates depend largely on the nature of the question asked to define the presence of the health condition, and the literature on the population burden of tinnitus and hearing difficulties is no different in this respect. Th... Read More about Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages.

One size does not fit all: developing common standards for outcomes in early-phase clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults (2019)
Journal Article
Hall, D. A., Hibbert, A., Smith, H., Haider, H. F., Londero, A., Mazurek, B., …Core Outcome Measures in Tinnitus (COMiT), . (2019). One size does not fit all: developing common standards for outcomes in early-phase clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults. Trends in Hearing, 23, 1-16. doi:10.1177/2331216518824827

Good practice in clinical trials advocates common standards for assessing and reporting condition-specific complaints (‘outcome domains’). For tinnitus there is no common standard. The COMiT’ID study created recommendations that are relevant to the m... Read More about One size does not fit all: developing common standards for outcomes in early-phase clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults.

Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs (2019)
Journal Article
Wilson, C. A., Berger, J. I., de Boer, J., Sereda, M., Palmer, A. R., Hall, D. A., & Wallace, M. N. (2019). Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs. Hearing Research, 374, 13-23. doi:10.1016/j.heares.2019.01.009

A common method for measuring changes in temporal processing sensitivity in both humans and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also the basis of a common method for detecting tinnitus in rodents. Howeve... Read More about Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs.

Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study (2019)
Journal Article
Hu, S., Anschuetz, L., Huth, M. E., Sznitman, R., Blaser, D., Kompis, M., …Wimmer, W. (2019). Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study. JMIR Research Protocols, 8(1), doi:10.2196/12270

Background: Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the in... Read More about Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study.

Betahistine for tinnitus (Review) (2018)
Journal Article
Wegner, I., Hall, D. A., Smit, A. L., McFerran, D., & Stegeman, I. (2018). Betahistine for tinnitus (Review). Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD013093.pub2

Background: Tinnitus is a symptom defined as the perception of sound in the absence of an external source. In England alone there are an estimated ¾ million general practice consultations every year where the primary complaint is tinnitus, equating t... Read More about Betahistine for tinnitus (Review).

Sound therapy (using amplification devices and/or sound generators) for tinnitus (2018)
Journal Article
Sereda, M., Xia, J., El Refaie, A., Hall, D. A., & Hoare, D. J. (2018). Sound therapy (using amplification devices and/or sound generators) for tinnitus. Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD013094.pub2

BACKGROUND: Tinnitus affects 10% to 15% of the adult population, with about 20% of these experiencing symptoms that negatively affect quality of life. In England alone there are an estimated ¾ million general practice consultations every year where t... Read More about Sound therapy (using amplification devices and/or sound generators) for tinnitus.

The COMiT'ID study: developing core outcome domains sets for clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults (2018)
Journal Article
Hall, D. A., Smith, H., Hibbert, A., Colley, V., Haider, H. F., Horobin, A. J., …Core Outcome Measures in Tinnitus (COMiT), . (2018). The COMiT'ID study: developing core outcome domains sets for clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults. Trends in Hearing, 22, 1-16. doi:10.1177/2331216518814384

Subjective tinnitus is a chronic heterogeneous condition that is typically managed using intervention approaches based on sound devices, psychologically informed therapies, or pharmaceutical products. For clinical trials, there are currently no commo... Read More about The COMiT'ID study: developing core outcome domains sets for clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults.

Pathophysiology of subjective tinnitus: triggers and maintenance (2018)
Journal Article
Haider, H. F., Bojić, T., Ribeiro, S. F., Paço, J., Hall, D., & Szczepek, A. J. (2018). Pathophysiology of subjective tinnitus: triggers and maintenance. Frontiers in Neuroscience, 12, doi:10.3389/fnins.2018.00866

Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a phantom perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms trigge... Read More about Pathophysiology of subjective tinnitus: triggers and maintenance.

The Noise Exposure Structured Interview (NESI): an instrument for the comprehensive estimation of lifetime noise exposure (2018)
Journal Article
Guest, H., Dewey, R. S., Plack, C. J., Couth, S., Prendergast, G., Bakay, W., & Hall, D. A. (2018). The Noise Exposure Structured Interview (NESI): an instrument for the comprehensive estimation of lifetime noise exposure. Trends in Hearing, 22, 1-10. doi:10.1177/2331216518803213

Lifetime noise exposure is generally quantified by self report. The accuracy of retrospective self report is limited by respondent recall, but is also bound to be influenced by reporting procedures. Such procedures are of variable quality in current... Read More about The Noise Exposure Structured Interview (NESI): an instrument for the comprehensive estimation of lifetime noise exposure.

Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review (2018)
Journal Article
Prayuenyong, P., Taylor, J. A., Pearson, S. E., Gomez, R., Patel, P. M., Hall, D. A., …Baguley, D. M. (2018). Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review. Frontiers in Oncology, 8, doi:10.3389/fonc.2018.00363

Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research... Read More about Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review.

Betahistine for tinnitus (Protocol) (2018)
Journal Article
Hall, D. A., Wegner, . I., Smit, A. L., McFerran, D., & Stegeman, I. (2018). Betahistine for tinnitus (Protocol). Cochrane Database of Systematic Reviews, 2018(8), doi:10.1002/14651858.CD013093

Background: Tinnitus describes 'ringing', 'whooshing' or 'hissing' sounds that are heard in the absence of any corresponding external sound. Between 5% and 43% of people experience this symptom and for some it has a significant negative impact on the... Read More about Betahistine for tinnitus (Protocol).

Sound therapy (using amplification devices and/or sound generators) for tinnitus in adults (Protocol) (2018)
Journal Article
Sereda, M., Xia, J., El Refaie, A., Hall, D. A., & Hoare, D. (2018). Sound therapy (using amplification devices and/or sound generators) for tinnitus in adults (Protocol). Cochrane Database of Systematic Reviews, 2018(8), doi:10.1002/14651858.CD013094

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of sound therapy (using amplification devices and/or sound generators) for tinnitus in adults.

A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others (2018)
Journal Article
Hall, D. A., Fackrell, K. L., Li, A. B., Thavayogan, R., Smith, S., Kennedy, V., …Haider, H. (2018). A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others. Health and Quality of Life Outcomes, 16, https://doi.org/10.1186/s12955-018-0888-9

Background: There are a large number of assessment tools for tinnitus, with little consensus on what it is important to measure and no preference for a minimum reporting standard. The item content of tinnitus assessment tools should seek to capture r... Read More about A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others.

The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint) (2018)
Other
Dewey, R. S., Hall, D. A., Guest, H., Prendergast, G., Plack, C. J., & Francis, S. T. (2018). The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint)

Background: Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is c... Read More about The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study (Preprint).