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The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds (2019)
Journal Article
Dewey, R. S., Francis, S. T., Guest, H., Prendergast, G., Millman, R. E., Plack, C. J., & Hall, D. A. (2020). The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. NeuroImage, 204, https://doi.org/10.1016/j.neuroimage.2019.116239

© 2019 In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several... Read More about The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds.

How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin (2019)
Journal Article
Hall, D. A., Kitterick, P. T., Heffernan, E., Fackrell, K., Lucas, L., & Ferguson, M. (2019). How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin. Otology and Neurotology, 40(4), e474-e481. https://doi.org/10.1097/MAO.0000000000001937

This short review article gives an introduction to some of the fundamental concepts and challenges facing measurement in hearing healthcare practice and research. The impact of hearing loss almost always extends beyond the sensory impairment itself,... Read More about How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin.

Content validity and readability of patient-reported questionnaire instruments of hearing disability (2019)
Journal Article
Manchaiah, V., Granberg, S., Grover, V., Saunders, G., & Hall, D. (2019). Content validity and readability of patient-reported questionnaire instruments of hearing disability. International Journal of Audiology, 58(9), 565-575. https://doi.org/10.1080/14992027.2019.1602738

Objective: The current study evaluates the content validity (i.e., domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognized procedures and tools. Design: A review of the literature to... Read More about Content validity and readability of patient-reported questionnaire instruments of hearing disability.

A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial (2019)
Journal Article
Hall, D., Ray, J., Watson, J., Sharman, A., Hutchison, J., Harris, P., …Large, C. H. (2019). A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial. Hearing Research, 377, 153-166. https://doi.org/10.1016/j.heares.2019.03.018

AUT00063 is an experimental new medicine that has been demonstrated to suppress spontaneous hyperactivity by modulating the action of voltage-gated potassium-channels in central auditory cortical neurons of a rodent model. This neurobiological proper... Read More about A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial.

Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ) (2019)
Journal Article
Genitsaridi, E., Partyka, M., Gallus, S., Lopez-Escamez, J. A., Schecklmann, M., Mielczarek, M., …Hall, D. A. (2019). Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ). Hearing Research, 377, 353-359. https://doi.org/10.1016/j.heares.2019.02.017

Background The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced... Read More about Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages (2019)
Journal Article
Biswas, R., Lugo, A., Gallus, S., Akeroyd, M. A., & Hall, D. A. (2019). Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages. Hearing Research, 377, 330-338. https://doi.org/10.1016/j.heares.2019.02.008

INTRODUCTION: Prevalence estimates depend largely on the nature of the question asked to define the presence of the health condition, and the literature on the population burden of tinnitus and hearing difficulties is no different in this respect. Th... Read More about Standardized questions in English for estimating tinnitus prevalence and severity, hearing difficulty and usage of healthcare resources, and their translation into 11 European languages.

One size does not fit all: developing common standards for outcomes in early-phase clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults (2019)
Journal Article
Hall, D. A., Hibbert, A., Smith, H., Haider, H. F., Londero, A., Mazurek, B., …Core Outcome Measures in Tinnitus (COMiT). (2019). One size does not fit all: developing common standards for outcomes in early-phase clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults. Trends in Hearing, 23, 1-16. https://doi.org/10.1177/2331216518824827

Good practice in clinical trials advocates common standards for assessing and reporting condition-specific complaints (‘outcome domains’). For tinnitus there is no common standard. The COMiT’ID study created recommendations that are relevant to the m... Read More about One size does not fit all: developing common standards for outcomes in early-phase clinical trials of sound-, psychology-, and pharmacology-based interventions for chronic subjective tinnitus in adults.

Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs (2019)
Journal Article
Wilson, C. A., Berger, J. I., de Boer, J., Sereda, M., Palmer, A. R., Hall, D. A., & Wallace, M. N. (2019). Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs. Hearing Research, 374, 13-23. https://doi.org/10.1016/j.heares.2019.01.009

A common method for measuring changes in temporal processing sensitivity in both humans and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also the basis of a common method for detecting tinnitus in rodents. Howeve... Read More about Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs.

Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study (2019)
Journal Article
Hu, S., Anschuetz, L., Huth, M. E., Sznitman, R., Blaser, D., Kompis, M., …Wimmer, W. (2019). Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study. JMIR Research Protocols, 8(1), Article e12270. https://doi.org/10.2196/12270

Background: Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the in... Read More about Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study.