Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair, Kevin D.; Rutherford, K.M.D.; Wallace, J.M.; Brameld, J.M.; St�ger, Reinhard; Alberio, Ramiro; Sweetman, Dylan; Gardner, David S.; Perry, V.E.A.; Adam, C.L.; Ashworth, C.J.; Robinson, J.E.; Dwyer, C.M.

doi:10.1071/RD16102

All Outputs (3)

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article
Corr, S. A., Gardner, D. S., Langley-Hobbs, S., Ness, M. G., Kitchener, A. C., & Sinclair, K. D. (2017). Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 7, Article 15685. https://doi.org/10.1038/s41598-017-15902-8

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More about Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.

Healthy ageing of cloned sheep (2016)
Journal Article
Sinclair, K. D., Corr, S., Gutierrez, C. G., Fisher, P., Lee, J., Rathbone, A., …Gardner, D. (2016). Healthy ageing of cloned sheep. Nature Communications, 7, 1-10. https://doi.org/10.1038/ncomms12359

The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detri... Read More about Healthy ageing of cloned sheep.

Epigenetics and developmental programming of welfare and production traits in farm animals (2016)
Journal Article
Sinclair, K. D., Rutherford, K., Wallace, J., Brameld, J., Stöger, R., Alberio, R., …Dwyer, C. (in press). Epigenetics and developmental programming of welfare and production traits in farm animals. Reproduction, Fertility and Development, 28(10), https://doi.org/10.1071/RD16102

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referr... Read More about Epigenetics and developmental programming of welfare and production traits in farm animals.