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Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy (2016)
Journal Article
Alexander, C., Luo, T., Magnusson, J., Bosquillon, C., Préat, V., Frédérick, R., & Vanbever, R. (2016). Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy. Pharmaceutical Research, 33(7), 1671-1681. doi:10.1007/s11095-016-1908-2

Purpose Pulmonary drug delivery is considered an attractive route of drug administration for lung cancer chemotherapy. However, fast clearance mechanisms result in short residence time of small molecule drugs in the lung. Therefore, achieving a sust... Read More