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Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves (2021)
Journal Article
Mesquita-Ribeiro, R., Fort, R. S., Rathbone, A., Farias, J., Lucci, C., James, V., …Dajas-Bailador, F. (2021). Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. RNA Biology, 18(sup2), 832-855. https://doi.org/10.1080/15476286.2021.2000792

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology,... Read More about Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

Spatiotemporal regulation of GSK3? levels by miRNA-26a controls axon development in cortical neurons (2020)
Journal Article
Lucci, C., Mesquita-Ribeiro, R., Rathbone, A., & Dajas-Bailador, F. (2020). Spatiotemporal regulation of GSK3? levels by miRNA-26a controls axon development in cortical neurons. Development, 147(3), https://doi.org/10.1242/dev.180232

© 2020. Published by The Company of Biologists Ltd. Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of pr... Read More about Spatiotemporal regulation of GSK3? levels by miRNA-26a controls axon development in cortical neurons.

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration (2019)
Journal Article
Loreto, A., Hill, C. S., Hewitt, V. L., Orsomando, G., Angeletti, C., Gilley, J., …Coleman, M. P. (2020). Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration. Neurobiology of Disease, 134, https://doi.org/10.1016/j.nbd.2019.104678

© 2019 The Authors Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these prot... Read More about Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.