Research Repository

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Epilepsy and associated mortality in patients with multiple sclerosis (2018)
Journal Article
Chou, I. J., Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., & Whitehouse, W. P. (2018). Epilepsy and associated mortality in patients with multiple sclerosis. European Journal of Neurology, doi:10.1111/ene.13821

Background and purpose: We aimed to determine the prevalence of epilepsy in patients with multiple sclerosis (MS) at diagnosis, the risk of developing epilepsy after the diagnosis of MS and the relative risk of mortality associated with epilepsy. Me... Read More

Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited (2018)
Journal Article
Constantinescu, C. S., & Gershkovich, P. (2018). Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited. European Journal of Neurology, 25(7), doi:10.1111/ene.13658. ISSN 1351-5101

Cannabinoids are compounds with pleiotropic properties that act on the cannabinoid receptors, CB1 and CB2, and are divided into endocannabinoids, the endogenous ligands of these receptors, synthetic cannabinoids and phytocannabinoids. The latter are... Read More

Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article
Chou, I., Lim, S., Tanasescu, R., Al-Radaideh, A., Mougin, O. E., Tench, C. R., …Constantinescu, C. S. (in press). Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging, doi:10.1111/jon.12474. ISSN 1051-2284

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More

Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis (2017)
Journal Article
Manouchehrinia, A., Tanasescu, R., Kareem, H., Jerca, O. P., Jabeen, F., Shafei, R., …Constantinescu, C. S. (in press). Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis. Journal of NeuroVirology, doi:10.1007/s13365-017-0569-1. ISSN 1538-2443

Varicella zoster virus (VZV) infection has been implicated in multiple sclerosis (MS), but direct causal involvement has been disputed. Nevertheless, knowledge of VZV exposure is important, given the risk of serious complications of first exposure wh... Read More

Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study (2017)
Journal Article
Tanasescu, R., Constantinescu, C. S., Tench, C. R., & Manouchehrinia, A. (2018). Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study. Nicotine and Tobacco Research, 20(5), doi:10.1093/ntr/ntx084. ISSN 1462-2203

Background: Smoking is associated with a more severe disease course in people with multiple sclerosis (MS). The magnitude of effect of smoking cessation on MS progression is unknown. The aim of this study was to quantify the impact of smoking cessati... Read More

Coordinate based random effect size meta-analysis of neuroimaging studies (2017)
Journal Article
Tench, C. R., Tanasescu, R., Constantinescu, C. S., Auer, D. P., & Cottam, W. J. (in press). Coordinate based random effect size meta-analysis of neuroimaging studies. NeuroImage, 153, doi:10.1016/j.neuroimage.2017.04.002. ISSN 1053-8119

Low power in neuroimaging studies can make them difficult to interpret, and Coordinate based meta-analysis (CBMA) may go some way to mitigating this issue. CBMA has been used in many analyses to detect where published functional MRI or voxel-based mo... Read More

Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis (2016)
Journal Article
Tanasescu, R., Midgley, A., Robins, R. A., & Constantinescu, C. S. (in press). Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis. Acta Neurologica Scandinavica, doi:10.1111/ane.12715. ISSN 0001-6314

Objectives. Interferon-β (IFN-β) is used in the treatment of multiple sclerosis (MS). IFN-β activation of signal transduction and activation of transcription (STAT)-4 is linked to its immunomodulatory effects. Previous studies suggest a type I IFN de... Read More

The future of multiple sclerosis treatments (2016)
Journal Article
Coclitu, C., Constantinescu, C. S., & Tanasescu, R. (in press). The future of multiple sclerosis treatments. Expert Review of Neurotherapeutics, 16(12), doi:10.1080/14737175.2016.1243056. ISSN 1473-7175

Introduction. There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently availab... Read More

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices (2016)
Journal Article
Chou, I., Wang, H., Whitehouse, W. P., & Constantinescu, C. S. (in press). Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16(7), doi:10.1007/s11910-016-0663-4. ISSN 1528-4042

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term... Read More

Functionally relevant white matter degradation in multiple sclerosis: a tract-based spatial meta-analysis (2015)
Journal Article
Welton, T., Kent, D., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2015). Functionally relevant white matter degradation in multiple sclerosis: a tract-based spatial meta-analysis. Radiology, 275(1), doi:10.1148/radiol.14140925. ISSN 0033-8419

Purpose To identify statistical consensus between published studies for distribution and functional relevance of tract white matter (WM) degradation in multiple sclerosis (MS). Materials and Methods By systematically searching online databases... Read More

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis (2015)
Journal Article
Cook, K. W., Crooks, J., Hussain, K., O'Brien, K., Braitch, M., Kareem, H., …Gran, B. (2015). Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis. Frontiers in Microbiology, 6, doi:10.3389/fmicb.2015.00052

Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compa... Read More

Coordinate based meta-analysis of functional neuroimaging data: false discovery control and diagnostics (2013)
Journal Article
Tench, C. R., Tanasescu, R., Auer, D. P., & Constantinescu, C. S. (2013). Coordinate based meta-analysis of functional neuroimaging data: false discovery control and diagnostics. PLoS ONE, 8(7), doi:10.1371/journal.pone.0070143. ISSN 1932-6203

Coordinate based meta-analysis (CBMA) is widely used to find regions of consistent activation across fMRI studies that have been selected for their functional relevance to a given hypothesis. Only reported coordinates (foci), and a model of their spa... Read More